7(S)-7-deoxy-4′-depropyl-7-{5-(2-nitrophenyl)-1,3,4-thiadiazol-2-ylthio}-4′-n-pentyllincomycin

Base Information

Chemical Name:7(S)-7-deoxy-4′-depropyl-7-{5-(2-nitrophenyl)-1,3,4-thiadiazol-2-ylthio}-4′-n-pentyllincomycin
CAS No.:941587-26-4
Molecular Formula:C₂₈H₄₁N₅O₇S₃
Molecular Weight:655.861
Hs Code.:

Synonyms:7(S)-7-deoxy-4′-depropyl-7-{5-(2-nitrophenyl)-1,3,4-thiadiazol-2-ylthio}-4′-n-pentyllincomycin

Suppliers and Price of 7(S)-7-deoxy-4′-depropyl-7-{5-(2-nitrophenyl)-1,3,4-thiadiazol-2-ylthio}-4′-n-pentyllincomycin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 7(S)-7-deoxy-4′-depropyl-7-{5-(2-nitrophenyl)-1,3,4-thiadiazol-2-ylthio}-4′-n-pentyllincomycin

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7(S)-7-deoxy-4′-depropyl-7-{5-(2-nitrophenyl)-1,3,4-thiadiazol-2-ylthio}-4′-n-pentyllincomycin

There total 6 articles about 7(S)-7-deoxy-4′-depropyl-7-{5-(2-nitrophenyl)-1,3,4-thiadiazol-2-ylthio}-4′-n-pentyllincomycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 941587-26-4
7(S)-7-deoxy-4′-depropyl-7-{5-(2-nitrophenyl)-1,3,4-thiadiazol-2-ylthio}-4′-n-pentyllincomycin

Guidance literature:

Reference yield: 85.7%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 941587-21-9
7(S)-1′-demethyl-7-deoxy-4′-depropyl-7-{5-(2-nitrophenyl)-1,3,4-thiadiazol-2-ylthio}-4′-n-pentyllincomycin

: 941587-26-4
7(S)-7-deoxy-4′-depropyl-7-{5-(2-nitrophenyl)-1,3,4-thiadiazol-2-ylthio}-4′-n-pentyllincomycin

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In methanol; water; at 20 ℃; for 1h;
DOI:10.1038/ja.2017.54

Reference yield:

: 1′-N-(tert-butoxycarbonyl)-1′-demethyl-4′-depropyl-4′-n-pentyllincomycin

: 941587-26-4
7(S)-7-deoxy-4′-depropyl-7-{5-(2-nitrophenyl)-1,3,4-thiadiazol-2-ylthio}-4′-n-pentyllincomycin

Guidance literature:: Multi-step reaction with 5 steps

1: 1,1,1,3,3,3-hexamethyl-disilazane; pyridine / 1 h / 20 °C

2: acetic acid / methanol / 2 h / 20 °C

3: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 24 h / 20 °C

4: trifluoroacetic acid / 0.5 h / 0 - 20 °C

5: acetic acid; sodium tris(acetoxy)borohydride / methanol; water / 1 h / 20 °C

With pyridine; sodium tris(acetoxy)borohydride; acetic acid; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; methanol; water;
DOI:10.1038/ja.2017.54