Boc-Thr(OBn)-Lys(2Cl,Z)-Proψ Arg(Tos)-OBn

Base Information

Chemical Name:Boc-Thr(OBn)-Lys(2Cl,Z)-Proψ Arg(Tos)-OBn
CAS No.:133704-44-6
Molecular Formula:C₅₅H₇₁ClN₈O₁₁S₂
Molecular Weight:1119.8
Hs Code.:

Boc-Thr(OBn)-Lys(2Cl,Z)-Proψ <CSNH>Arg(Tos)-OBn

Synonyms:Boc-Thr(OBn)-Lys(2Cl,Z)-Proψ Arg(Tos)-OBn

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Chemical Property of Boc-Thr(OBn)-Lys(2Cl,Z)-Proψ Arg(Tos)-OBn

Chemical Property:

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Technology Process of Boc-Thr(OBn)-Lys(2Cl,Z)-Proψ Arg(Tos)-OBn

There total 8 articles about Boc-Thr(OBn)-Lys(2Cl,Z)-Proψ Arg(Tos)-OBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15260-10-3
N-Boc-O-benzyl-L-threonine

: 133704-43-5
H-Lys(2Cl,Z)-Proψ Arg(Tos)-OBn

: 133704-44-6
Boc-Thr(OBn)-Lys(2Cl,Z)-Proψ Arg(Tos)-OBn

Guidance literature:: With dicyclohexyl-carbodiimide; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 0 ℃; Yield given;
DOI:10.1016/S0040-4020(01)81544-1

Reference yield:

: 29388-63-4
H-Arg(Tos)-OBzl

: 133704-44-6
Boc-Thr(OBn)-Lys(2Cl,Z)-Proψ Arg(Tos)-OBn

Guidance literature:: Multi-step reaction with 5 steps

1: dimethylformamide / 1.) 0 deg C, 2.3 hrs; 2.) room temp.

2: 2.) NaHCO₃ / 1.) TFA, room temp., 1.5 hrs; 2.) water, dichloromethane, room temp, 0.5 hr

3: DCC / HOBt / dimethylformamide / 0 °C

4: 2.) NaHCO₃ / 1.) TFA, room temp., 1.5 hrs; 2.) water, dichloromethane, room temp, 0.5 hr

5: DCC / HOBt / dimethylformamide / 0 °C

With sodium hydrogencarbonate; dicyclohexyl-carbodiimide; benzotriazol-1-ol; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)81544-1

Reference yield:

: 13836-37-8
Boc-Arg(Tos)-OH

: 133704-44-6
Boc-Thr(OBn)-Lys(2Cl,Z)-Proψ Arg(Tos)-OBn

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) Cs₂CO₃ / 1.) water, MeOH; 2.) DMF, 8 hrs

2: 2.) NaHCO₃ / 1.) TFA, room temp., 1.5 hrs; 2.) water, dichloromethane, room temp, 0.5 hr

3: dimethylformamide / 1.) 0 deg C, 2.3 hrs; 2.) room temp.

4: 2.) NaHCO₃ / 1.) TFA, room temp., 1.5 hrs; 2.) water, dichloromethane, room temp, 0.5 hr

5: DCC / HOBt / dimethylformamide / 0 °C

6: 2.) NaHCO₃ / 1.) TFA, room temp., 1.5 hrs; 2.) water, dichloromethane, room temp, 0.5 hr

7: DCC / HOBt / dimethylformamide / 0 °C

With sodium hydrogencarbonate; caesium carbonate; dicyclohexyl-carbodiimide; benzotriazol-1-ol; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)81544-1