N-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-5-bromopyrimidine-2-carboxamide hydrochloride

Base Information

Chemical Name:N-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-5-bromopyrimidine-2-carboxamide hydrochloride
CAS No.:1262855-96-8
Molecular Formula:C₁₈H₁₆BrF₄N₅O₂*ClH
Molecular Weight:526.716
Hs Code.:

N-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-5-bromopyrimidine-2-carboxamide hydrochloride

Synonyms:N-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-5-bromopyrimidine-2-carboxamide hydrochloride

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Chemical Property of N-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-5-bromopyrimidine-2-carboxamide hydrochloride

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Technology Process of N-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-5-bromopyrimidine-2-carboxamide hydrochloride

There total 32 articles about N-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-5-bromopyrimidine-2-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262859-71-1
((2R,5R)-5-{5-[(5-bromo-pyrimidine-2-carbonyl)-amino]-2-fluoro-phenyl}-2,5-di-methyl-2-trifluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester

: 1262855-96-8
N-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-5-bromopyrimidine-2-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 40 - 45 ℃; for 6h;

Reference yield:

: 1262859-69-7
tert-butyl ((2R,5R)-5-(2-fluoro-5-nitrophenyl)-2,5-dimethyl-2-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-yl)carbamate

: 1262855-96-8
N-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-5-bromopyrimidine-2-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran; isopropyl alcohol / 4 h / 50 °C

2: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 25 °C

3: hydrogenchloride / 1,4-dioxane / 6 h / 40 - 45 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1262859-67-5
(2R,5R)-5-(2-fluorophenyl)-2,5-dimethyl-2-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-amine

: 1262855-96-8
N-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-5-bromopyrimidine-2-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: potassium nitrate / sulfuric acid / 2 h / 25 °C / Cooling with ice

2: triethylamine / acetonitrile / 16 h / 25 °C

3: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran; isopropyl alcohol / 4 h / 50 °C

4: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 25 °C

5: hydrogenchloride / 1,4-dioxane / 6 h / 40 - 45 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; triethylamine; N-ethyl-N,N-diisopropylamine; sulfuric acid; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;