Technology Process of (2R,5R)-5-(2-fluorophenyl)-2,5-dimethyl-2-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-amine
There total 18 articles about (2R,5R)-5-(2-fluorophenyl)-2,5-dimethyl-2-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen; sodium acetate;
palladium 10% on activated carbon;
In
methanol;
at 50 ℃;
for 6h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 - 5 °C / Inert atmosphere
1.2: 3 h / 25 °C / Inert atmosphere
2.1: sodium hydroxide / water; tetrahydrofuran / 2.5 h / 0 - 20 °C
3.1: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 24 h / 0 - 25 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere
4.2: 16 h / 25 °C
5.1: ammonia / methanol / 16 h / 50 °C
6.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere
7.1: potassium carbonate; N-Acetylcysteine / methanol / 16 h / 80 °C
8.1: hydrogen; sodium acetate / palladium 10% on activated carbon / methanol / 6 h / 50 °C
With
lithium aluminium tetrahydride; N-Acetylcysteine; ammonia; hydrogen; sodium acetate; sodium hydride; potassium carbonate; triethylamine; triphenylphosphine; trifluoroacetic anhydride; sodium hydroxide; diethylazodicarboxylate;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydroxide / water; tetrahydrofuran / 2.5 h / 0 - 20 °C
2.1: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 24 h / 0 - 25 °C
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere
3.2: 16 h / 25 °C
4.1: ammonia / methanol / 16 h / 50 °C
5.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere
6.1: potassium carbonate; N-Acetylcysteine / methanol / 16 h / 80 °C
7.1: hydrogen; sodium acetate / palladium 10% on activated carbon / methanol / 6 h / 50 °C
With
N-Acetylcysteine; ammonia; hydrogen; sodium acetate; sodium hydride; potassium carbonate; triethylamine; triphenylphosphine; trifluoroacetic anhydride; sodium hydroxide; diethylazodicarboxylate;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
