Technology Process of 3-[(R)-2-((S)-2-Benzoylamino-3-m-tolyl-propionylamino)-2-cyano-ethoxymethyl]-benzoic acid allyl ester
There total 11 articles about 3-[(R)-2-((S)-2-Benzoylamino-3-m-tolyl-propionylamino)-2-cyano-ethoxymethyl]-benzoic acid allyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 5 steps
1.1: NaH / dimethylformamide; hexane / 2 h / 20 °C
1.2: dimethylformamide; hexane / 2 h / 20 °C
2.1: aq. AcOH / 16 h / pH 5 / Heating
2.2: 3.55 g / Alcalase 2.4L; aq. NaHCO3 / 2.5 h / 25 - 27 °C
3.1: 72 percent / N-methylmorpholine; HOAt; EDCI / CH2Cl2 / 20 °C
4.1: 100 percent / HCOOH / 6 h / 20 °C
5.1: N-methylmorpholine / CH2Cl2 / 2 h / 20 °C
With
4-methyl-morpholine; formic acid; 1-hydroxy-7-aza-benzotriazole; sodium hydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010206q
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: K2CO3 / acetone / 2 h / Heating
1.2: 76 percent / NaI / acetone / 6.5 h
2.1: NaH / dimethylformamide / 0.58 h / 0 - 20 °C
2.2: dimethylformamide / 0.5 h / 0 - 20 °C
3.1: N-methylmorpholine / CH2Cl2 / 0.25 h
4.1: NH3(g) / CH2Cl2 / 0.5 h / 20 °C
5.1: oxalyl chloride; pyridine / dimethylformamide / 0.75 h / 0 °C
6.1: HCOOH / 6 h / 20 °C
7.1: 72 percent / N-methylmorpholine; HOAt; EDCI / CH2Cl2 / 20 °C
8.1: 100 percent / HCOOH / 6 h / 20 °C
9.1: N-methylmorpholine / CH2Cl2 / 2 h / 20 °C
With
4-methyl-morpholine; pyridine; formic acid; 1-hydroxy-7-aza-benzotriazole; oxalyl dichloride; ammonia; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm010206q
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: NaH / dimethylformamide / 0.58 h / 0 - 20 °C
1.2: dimethylformamide / 0.5 h / 0 - 20 °C
2.1: N-methylmorpholine / CH2Cl2 / 0.25 h
3.1: NH3(g) / CH2Cl2 / 0.5 h / 20 °C
4.1: oxalyl chloride; pyridine / dimethylformamide / 0.75 h / 0 °C
5.1: HCOOH / 6 h / 20 °C
6.1: 72 percent / N-methylmorpholine; HOAt; EDCI / CH2Cl2 / 20 °C
7.1: 100 percent / HCOOH / 6 h / 20 °C
8.1: N-methylmorpholine / CH2Cl2 / 2 h / 20 °C
With
4-methyl-morpholine; pyridine; formic acid; 1-hydroxy-7-aza-benzotriazole; oxalyl dichloride; ammonia; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010206q
