[1-(cyclohexylmethyl-carbamoyl)-1-methylethyl]carbamic acid benzyl ester

Base Information

• Chemical Name: [1-(cyclohexylmethyl-carbamoyl)-1-methylethyl]carbamic acid benzyl ester
• CAS No.: 101715-65-5
• Molecular Formula: C₁₈H₂₆N₂O₃
• Molecular Weight: 318.416
• Mol file: 101715-65-5.mol

Synonyms:[1-(cyclohexylmethyl-carbamoyl)-1-methylethyl]carbamic acid benzyl ester

Chemical Property of [1-(cyclohexylmethyl-carbamoyl)-1-methylethyl]carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of [1-(cyclohexylmethyl-carbamoyl)-1-methylethyl]carbamic acid benzyl ester

There total 4 articles about [1-(cyclohexylmethyl-carbamoyl)-1-methylethyl]carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

cyclohexylamine (108-91-8,157973-60-9) + 2-(benzyloxy)-4,4-dimethyloxazol-5(4H)-one (367274-58-6) → [1-(cyclohexylmethyl-carbamoyl)-1-methylethyl]carbamic acid benzyl ester (101715-65-5)

Guidance literature:

In toluene; at 70 ℃; for 3h; Reagent/catalyst; Temperature;

DOI:10.1007/s12272-018-1031-5

Reference yield: 61.0%

Z-Aib-OH (15030-72-5) + cyclohexylamine (108-91-8,157973-60-9) → [1-(cyclohexylmethyl-carbamoyl)-1-methylethyl]carbamic acid benzyl ester (101715-65-5)

Guidance literature:

With PS-N-isobutoxycarbonyl-2-isobutoxy-1,2-dihydroquinoline; In acetonitrile; at 20 ℃; for 24h;

DOI:10.1016/j.tet.2007.06.019

Reference yield: 10.0%

Z-Aib-OH (15030-72-5) + cyclohexylamine (108-91-8,157973-60-9) → [1-(cyclohexylmethyl-carbamoyl)-1-methylethyl]carbamic acid benzyl ester (101715-65-5) + 2-(benzyloxy)-4,4-dimethyloxazol-5(4H)-one (367274-58-6)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 - 80 ℃;

DOI:10.1007/s12272-018-1031-5

upstream raw materials:

Z-Aib-OH

cyclohexylamine

2-(benzyloxy)-4,4-dimethyloxazol-5(4H)-one

Refernces

• 1、 Valeur, Eric,Bradley, Mark. "PS-IIDQ: a supported coupling reagent for efficient and general amide bond formation". . p. 8855 - 8871. Retrieved 2008/02/11.