(2E)-3-methylthio-2-(4-naphtho[1,2-d]furan-2-yl-1,3-thiazol-2-yl)-3-(phenylamino)prop-2-enenitrile

Base Information

• Chemical Name: (2E)-3-methylthio-2-(4-naphtho[1,2-d]furan-2-yl-1,3-thiazol-2-yl)-3-(phenylamino)prop-2-enenitrile
• CAS No.: 877225-95-1
• Molecular Formula: C₂₅H₁₇N₃OS₂
• Molecular Weight: 439.561

Synonyms:(2E)-3-methylthio-2-(4-naphtho[1,2-d]furan-2-yl-1,3-thiazol-2-yl)-3-(phenylamino)prop-2-enenitrile

Chemical Property of (2E)-3-methylthio-2-(4-naphtho[1,2-d]furan-2-yl-1,3-thiazol-2-yl)-3-(phenylamino)prop-2-enenitrile

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Technology Process of (2E)-3-methylthio-2-(4-naphtho[1,2-d]furan-2-yl-1,3-thiazol-2-yl)-3-(phenylamino)prop-2-enenitrile

There total 2 articles about (2E)-3-methylthio-2-(4-naphtho[1,2-d]furan-2-yl-1,3-thiazol-2-yl)-3-(phenylamino)prop-2-enenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2-(4-naphtho[1,2-d]furan-2-yl-1,3-thiazol-2-yl)ethanenitrile (877225-72-4) + phenyl isothiocyanate (103-72-0) + methyl iodide (74-88-4) → (2E)-3-methylthio-2-(4-naphtho[1,2-d]furan-2-yl-1,3-thiazol-2-yl)-3-(phenylamino)prop-2-enenitrile (877225-95-1)

Guidance literature:

2-(4-naphtho[1,2-d]furan-2-yl-1,3-thiazol-2-yl)ethanenitrile; phenyl isothiocyanate; With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1080/10426500590885066

Reference yield:

2-bromo-1-naphtho[1,2-d]furan-2-ylethan-1-one (865367-56-2) → (2E)-3-methylthio-2-(4-naphtho[1,2-d]furan-2-yl-1,3-thiazol-2-yl)-3-(phenylamino)prop-2-enenitrile (877225-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 69 percent / ethanol / 2 h / Heating

2.1: potassium hydroxide / dimethylformamide / 20 °C

2.2: 58 percent / dimethylformamide / 2 h / 20 °C

With potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1080/10426500590885066

Reference yield: 72.0%

(2E)-3-methylthio-2-(4-naphtho[1,2-d]furan-2-yl-1,3-thiazol-2-yl)-3-(phenylamino)prop-2-enenitrile (877225-95-1) → [5-amino-4-(4-naphtho[1,2-d]furan-2-yl-1,3-thiazol-2-yl)pyrazol-3-yl]phenylamine

Guidance literature:

With hydrazine hydrate; In ethanol; for 4h; Heating;

DOI:10.1080/10426500590885066

upstream raw materials:

2-(4-naphtho[1,2-d]furan-2-yl-1,3-thiazol-2-yl)ethanenitrile

phenyl isothiocyanate

methyl iodide

2-bromo-1-naphtho[1,2-d]furan-2-ylethan-1-one

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