(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-fluorophenyl)boronic acid

Base Information

Chemical Name:(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-fluorophenyl)boronic acid
CAS No.:1423007-41-3
Molecular Formula:C₂₆H₂₃BF₂N₂O₆S
Molecular Weight:540.352
Hs Code.:

Synonyms:(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-fluorophenyl)boronic acid

Suppliers and Price of (4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-fluorophenyl)boronic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-fluorophenyl)boronic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-fluorophenyl)boronic acid

There total 17 articles about (4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-fluorophenyl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1423007-45-7
5-cyclopropyl-6-(N-(3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methylsulfonamido)-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

: 1423007-41-3
(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-fluorophenyl)boronic acid

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 24h;

Reference yield:

: 691856-35-6
5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-(methylsulfonamido)benzofuran-3-carboxamide

: 1423007-41-3
(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-fluorophenyl)boronic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / water; 1,2-dimethoxyethane / 24 h / 100 °C

2.1: tin(ll) chloride; ethanol / ethyl acetate / 3 h / Reflux

3.1: hydrogen bromide; sodium nitrite / acetonitrile; water / 0.5 h / 0 °C / Reflux

3.2: 2 h / 0 °C / Reflux

4.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere

5.1: hydrogenchloride / water; tetrahydrofuran / 24 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ethanol; hydrogen bromide; potassium acetate; potassium carbonate; tin(ll) chloride; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; ethyl acetate; acetonitrile; 3.1: |Sandmeyer Reaction;

Reference yield:

: 1423007-42-4
5-cyclopropyl-6-[N-(3-fluoro-4-nitrophenyl)methanesulfonamido]-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

: 1423007-41-3
(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-fluorophenyl)boronic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: tin(ll) chloride; ethanol / ethyl acetate / 3 h / Reflux

2.1: hydrogen bromide; sodium nitrite / acetonitrile; water / 0.5 h / 0 °C / Reflux

2.2: 2 h / 0 °C / Reflux

3.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere

4.1: hydrogenchloride / water; tetrahydrofuran / 24 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ethanol; hydrogen bromide; potassium acetate; tin(ll) chloride; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; acetonitrile; 2.1: |Sandmeyer Reaction;