Argipressin tannate

Base Information

• Chemical Name: Argipressin tannate
• CAS No.: 113-79-1
• Molecular Formula: C46H65N15O12S2
• Molecular Weight: 1084.25
• Hs Code.: 2937190000
• European Community (EC) Number: 204-035-4
• Wikipedia: Vasopressin_(medication)
• NCI Thesaurus Code: C166779
• Mol file: 113-79-1.mol

Synonyms:Arg Vasopressin;Arg-Vasopressin;Arginine Vasopressin;Argipressin;Argipressin Tannate;Vasopressin, Arginine

Chemical Property of Argipressin tannate

Chemical Property:

• Appearance/Colour: White powder
• PKA: 9.90±0.15(Predicted)
• Flash Point: 113℃
• PSA: 512.03000
• Density: 1.59 g/cm³
• LogP: 1.16100
• Storage Temp.: 2-8°C
• XLogP3: -4.8
• Hydrogen Bond Donor Count: 14
• Hydrogen Bond Acceptor Count: 16
• Rotatable Bond Count: 19
• Exact Mass: 1083.43785492
• Heavy Atom Count: 75
• Complexity: 2070

Purity/Quality:

98% ^*data from raw suppliers

Antidiuretic Hormone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N
• Recent ClinicalTrials: Cardiac Output Response to Vasopressin Infusion In Abdominal Surgery Patients Under Mechanical Ventilation
• Recent EU Clinical Trials: HYdrocortisone and VAsopressin in Post-RESuscitation Syndrome
• Uses: Hormone (antidiuretic). [Arg8]-Vasopressin solution was used as an antigen for preparing preadsorbed antisera for immunocytochemistry. The product was used in L6 cell culture of the C5 subclone for differentiation studies.
• Indications: ADH (vasopressin) is released primarily in response to increases in plasma osmolarity or decreases in blood volume. It produces its antidiuretic activity in the kidney, causing the cortical and medullary parts of the collecting duct to become more permeable to water, thereby increasing water reabsorption, reducing serum osmolarity, and increasing its volume. It produces this effect by binding to a subset of vasopressin receptors called V2 that have relatively high affinity for the hormone. ADH also has actions at sites other than the kidney. V2 receptors also mediate an increase in circulating levels of two proteins involved in blood coagulation: factor VIII and von Willebrand’s factor.At higher concentrations, ADH interacts with V1 receptors to cause a general constriction of most blood vessels. It also interacts with V3 (or V1b) receptors to increase ACTH release, although the major control of ACTH release occurs through corticotropin-releasing hormone.
• Clinical Use: Because it is stable, desmopressin is preferred for treatments especially if pressor effects are not desired. The primary indication for therapy is central diabetes insipidus, a disorder that results when ADH secretion is reduced and that is characterized by polydipsia, polyuria, and dehydration. Desmopressin is also used to reduce primary nocturnal enuresis, or bedwetting, in children. It is useful in people with mild hemophilia A or with some types of von Willebrand’s disease, in which von Willebrand’s factor is present at low levels. In these cases, desmopressin is given when excessive bleeding occurs or before surgery to help reduce bleeding indirectly by increasing the amounts of coagulation factors. A possible adverse effect of desmopressin is water intoxication if too much is taken. ADH antagonists, including nonpeptide analogues that may be taken orally, have been developed with specificity for each of the receptor types. In the future, those that block V1 receptors may be useful in treating hypertension, and those that block V2 receptors may be useful in any condition of excessive water retention or hyponatremia, for which so far there is no satisfactory therapeutic treatment.

Technology Process of Argipressin tannate

There total 11 articles about Argipressin tannate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (34223-44-4) → Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (113-79-1,5591-81-1,66513-06-2,66513-07-3,76023-59-1,89576-32-9)

Guidance literature:

With [Pt(en)2Cl₂]⁽²⁺⁾; ethylenediaminetetraacetic acid; sodium chloride; In phosphate buffer; pH=4 - 7;

DOI:10.1021/ja0008618

Reference yield: 76.0%

→ Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (113-79-1,5591-81-1,66513-06-2,66513-07-3,76023-59-1,89576-32-9)

Guidance literature:

DOI:10.1016/S0040-4039(99)00926-0

Reference yield:

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (34223-44-4) + Captopril disulfide (64806-05-9) → Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (113-79-1,5591-81-1,66513-06-2,66513-07-3,76023-59-1,89576-32-9) + captopril (62571-86-2)

Guidance literature:

In water; at 25 ℃; for 5h; Equilibrium constant; pH 7.0;

DOI:10.1006/bioo.1995.1009

upstream raw materials:

benzyloxycarbonyl-S-(2,4,6-trimethylbenzyl)-L-cysteinyl-O-tert-butyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-S-(2,4,6-trimethylbenzyl)-L-cysteinyl-L-prolyl-N^G-p-toluenesulfonyl-L-arginyl-glycine amide

Z-Cys(Bzl)-Tyr(Bzl)-Phe-Gln-Asn-Cys(Bzl)-Pro-Arg(Tos)-Gly-NH₂

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH₂

Captopril disulfide

Downstream raw materials:

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH₂

Captopril disulfide

Refernces

• 1、 Shi, Tiesheng,Rabenstein, Dallas L.. "Discovery of a highly selective and efficient reagent for formation of intramolecular disulfide bonds in peptides". . p. 6809 - 6815. Retrieved 2007/10/03.
• 2、 Maruyama, Toshihiro,Ikeo, Takayoshi,Ueki, Masaaki. "A rapid and facile method for the preparation of peptide disulfides". . p. 5031 - 5034. Retrieved 2007/10/03.