(1R,2R)-2-[N-(2-diphenylaminobenzoyl)amino]cyclohexylcarbamic acid tert-butyl ester

Base Information

Chemical Name:(1R,2R)-2-[N-(2-diphenylaminobenzoyl)amino]cyclohexylcarbamic acid tert-butyl ester
CAS No.:315179-51-2
Molecular Formula:C₃₀H₃₅N₃O₃
Molecular Weight:485.626
Hs Code.:

Synonyms:(1R,2R)-2-[N-(2-diphenylaminobenzoyl)amino]cyclohexylcarbamic acid tert-butyl ester

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Chemical Property of (1R,2R)-2-[N-(2-diphenylaminobenzoyl)amino]cyclohexylcarbamic acid tert-butyl ester

Chemical Property:

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Technology Process of (1R,2R)-2-[N-(2-diphenylaminobenzoyl)amino]cyclohexylcarbamic acid tert-butyl ester

There total 7 articles about (1R,2R)-2-[N-(2-diphenylaminobenzoyl)amino]cyclohexylcarbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 17626-44-7
2-(N,N-diphenylamino)benzoic acid

: 146504-07-6
tert-butyl ((1R,2R)-2-aminocyclohexyl)carbamate

: 315179-51-2
(1R,2R)-2-[N-(2-diphenylaminobenzoyl)amino]cyclohexylcarbamic acid tert-butyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1021/jo000821m

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 315179-51-2
(1R,2R)-2-[N-(2-diphenylaminobenzoyl)amino]cyclohexylcarbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 7.38 g / N,N-dimethyl-4-aminopyridine / tetrahydrofuran / 24 h / 20 °C

2: 98 percent / H₂ / Pd/C / ethanol / 2 h / 20 °C / 760.05 Torr

3: 97 percent / dicyclohexylcarbodiimide; DMAP / CH₂Cl₂ / 2 h / 0 - 20 °C

With dmap; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; 1: Acylation / 2: Catalytic hydrogenation / 3: Acylation;
DOI:10.1021/jo000821m

Reference yield:

: 315179-46-5
((1R,2R)-2-Benzyloxycarbonylamino-cyclohexyl)-carbamic acid benzyl ester

: 315179-51-2
(1R,2R)-2-[N-(2-diphenylaminobenzoyl)amino]cyclohexylcarbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 7.38 g / N,N-dimethyl-4-aminopyridine / tetrahydrofuran / 24 h / 20 °C

2: 98 percent / H₂ / Pd/C / ethanol / 2 h / 20 °C / 760.05 Torr

3: 97 percent / dicyclohexylcarbodiimide; DMAP / CH₂Cl₂ / 2 h / 0 - 20 °C

With dmap; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; 1: Acylation / 2: Catalytic hydrogenation / 3: Acylation;
DOI:10.1021/jo000821m