146504-07-6

Basic information

• Product Name: (1R,2R)-trans-N-Boc-1,2-Cyclohexanediamine
• Synonyms: (1R,2R)-trans-N-Boc-1,2-Cyclohexanediamine;(1R)-trans-N-Boc-1,2-diaminocyclohexane;Trans (1R,2R)-1N-Boc-cyclohexane-1,2-diamine;Carbamic acid, N-[(1R,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester;N-Boc-1R,2R-Cyclohexanediamine;((1R,2R)-2-Aminocyclohexyl)-carbamic acid tert-butyl ester;(1R,2R)-(-)-N-(t-Butoxycarbonyl)-1,2-cyclohexanediamine;(1R,2R)-N-tert.-Butoxycarbonylcyclohexane-1,2-diamine
• CAS NO: 146504-07-6
• Molecular Formula: C₁₁H₂₂N₂O₂
• Molecular Weight: 214.3046
• Mol File: 146504-07-6.mol
• Article Data: 30

Chemical Properties

• Melting Point: 114-115℃
• Boiling Point: 322.1 °C at 760 mmHg
• Flash Point: 148.6 °C
• Appearance: /
• Density: 1.02 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 12.26±0.40(Predicted)
• BRN: 7023564
• CAS DataBase Reference: (1R,2R)-trans-N-Boc-1,2-Cyclohexanediamine(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-trans-N-Boc-1,2-Cyclohexanediamine(146504-07-6)
• EPA Substance Registry System: (1R,2R)-trans-N-Boc-1,2-Cyclohexanediamine(146504-07-6)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3259 8/PG 3
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 146504-07-6(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

(1R,2R)-trans-N-Boc-1,2-cyclohexanediamine can be used as:An organocatalyst in the intramolecular desymmetrization of cyclohexanones to yield 2-azabicyclo[3.3.1]nonane.A starting material in the synthesis of a chiral nickel catalyst applicable for the Michael addition reaction of 1,3-dicarbonyl compounds to yield nitroalkenes.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 191480-63-4 (1R,2R)-1,2-diaminocyclohexane monohydrochloride 
• 21436-03-3 (S,S)-1,2-diaminocyclohexane 
• 694-83-7 rac-diaminocyclohexane 
• 20439-47-8 (1R,2R)-1,2-diaminocyclohexane 
• 32044-22-7 (1R,2R)-1,2-diaminocyclohexane tartrate 
• 1121-22-8 trans-1,2-Diaminocyclohexane 
• 34619-03-9 tert-butyldicarbonate 
• 315179-46-5 ((1R,2R)-2-Benzyloxycarbonylamino-cyclohexyl)-carbamic acid benzyl ester 
• 315179-47-6 C₂₂H₂₅N₂O₄C₅H₉O₂ 
• 80994-44-1 {[(tert-butoxycarbonyl)oxy]amino}(phenyl)acetonitrile 

Downstream Products

• 249931-84-8 N-(2-hydroxylbenzaldehyde)-1-amino-2-cyclohexaneimine 
• 180683-66-3 {((1R,2R)-2-tert-Butoxycarbonylamino-cyclohexyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid methyl ester 
• 323187-52-6 2,2-Dimethyl-N,N'-bis-((1R,2R)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-cyclohexyl)-malonamide 
• 323187-51-5 N,N'-Bis-((1R,2R)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-cyclohexyl)-oxalamide 
• 323187-56-0 N¹,N³-bis((1R,2R)-2-aminocyclohexyl)-2,2-dimethylmalonamide 
• 323187-50-4 oxalyl (1R,2R)-N,N'-bis[2-(amino)cyclohexyl]diamide 
• 323187-46-8 C₂₇H₄₈N₄O₆ 
• 315179-50-1 (1R,2R)-2-[N-(2-dimethylaminobenzoyl)amino]cyclohexylcarbamic acid tert-butyl ester 
• 323187-43-5 C₂₄H₄₂N₄O₆ 
• 315179-51-2 (1R,2R)-2-[N-(2-diphenylaminobenzoyl)amino]cyclohexylcarbamic acid tert-butyl ester 
• 315179-52-3 (1R,2R)-2-[N-(2-diphenylphosphanylbenzoyl)amino]cyclohexylcarbamic acid tert-butyl ester 
• 213765-35-6 N,N'-bis<2'-(t-butoxycarbonyl)-(1'R,2'R)-diaminocyclohexyl>isophthalamide 
• 180683-65-2 ((1R,2R)-2-tert-Butoxycarbonylamino-cyclohexylamino)-acetic acid methyl ester 
• 161579-52-8 5-((1R,2R)-2-tert-Butoxycarbonylamino-cyclohexylcarbamoyl)-isophthalic acid dimethyl ester 

Relevant articles and documents

Charge and Spin Transport in an Organic Molecular Square

Understanding electronic communication among multiple chromophoric and redox units requires construction of well-defined molecular architectures. Herein, we report the modular synthesis of a shape-persistent chiral organic square composed of four naphthal

Characteristics of gelation by amides based on trans-1,2-diaminocyclohexane: The importance of different substituents

Six diamides were prepared from trans-(1R,2R)-1,2-diaminocyclohexane and the corresponding racemate and were subsequently used as gelators. Three chiral compounds and their racemates were prepared. One of the chiral compounds and its racemate contained tw

Harnessing the Power of the Asymmetric Grignard Synthesis of Tertiary Alcohols: Ligand Development and Improved Scope Exemplified by One-Step Gossonorol Synthesis

A series of N-substituted cyclohexyldiaminophenolic ligands for the asymmetric Grignard synthesis of tertiary alcohols is reported. The 2,5-dimethylpyrrole-decorated ligand led to improved enantioselectivities and broadened the scope of the methodology. As an exemplar, we report an unprecedented highly selective one-step synthesis of gossonorol in 93% ee, also constituting the shortest formal syntheses of natural products boivinianin B and yingzhaosu C.

IMIDAZOLIDIN-2-ONE COMPOUNDS AS PRMT5 MODULATORS

The present invention relates to the derivatives of compound of formula (I) and pharmaceutically acceptable salts thereof. The present invention further provides the methods of preparation of compound of formula (I) and use thereof as PRMT5 inhibitors. Th