(3-chloro-4-{4-[2-(2,4-dichloro-phenoxy)-ethylcarbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid

Base Information

Chemical Name:(3-chloro-4-{4-[2-(2,4-dichloro-phenoxy)-ethylcarbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid
CAS No.:870194-70-0
Molecular Formula:C₂₆H₁₉Cl₃N₂O₅
Molecular Weight:545.806
Hs Code.:

Synonyms:(3-chloro-4-{4-[2-(2,4-dichloro-phenoxy)-ethylcarbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid

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Chemical Property of (3-chloro-4-{4-[2-(2,4-dichloro-phenoxy)-ethylcarbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid

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Technology Process of (3-chloro-4-{4-[2-(2,4-dichloro-phenoxy)-ethylcarbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid

There total 14 articles about (3-chloro-4-{4-[2-(2,4-dichloro-phenoxy)-ethylcarbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 870194-95-9
(3-chloro-4-{4-[2-(2,4-dichloro-phenoxy)-ethylcarbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid methyl ester

: 870194-70-0
(3-chloro-4-{4-[2-(2,4-dichloro-phenoxy)-ethylcarbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1016/j.bmcl.2006.05.055

Reference yield:

: 496856-45-2
(3-chloro-4-cyanophenyl)acetic acid methyl ester

: 870194-70-0
(3-chloro-4-{4-[2-(2,4-dichloro-phenoxy)-ethylcarbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 55 percent / HCO₂H / Raney-Ni / 10 h / 110 °C

2.1: 90 percent / NH₂OH*HCl; Na₂CO₃ / H₂O / 2 h / 20 °C

3.1: NCS; HCl / dimethylformamide / 0.5 h / 20 °C

4.1: KN(TMS)2 / diethyl ether / 1 h / 20 °C

4.2: acetonitrile / 3 h / 20 °C

5.1: 95 percent / aq. LiOH / tetrahydrofuran / 12 h / 20 °C

With hydrogenchloride; lithium hydroxide; N-chloro-succinimide; formic acid; hydroxylamine hydrochloride; potassium hexamethylsilazane; sodium carbonate; nickel; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.05.055

Reference yield:

: 496856-44-1
methyl 2-(3-chloro-4-(triuoromethylsulfonyloxy)phenyl)acetate

: 870194-70-0
(3-chloro-4-{4-[2-(2,4-dichloro-phenoxy)-ethylcarbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: 70 percent / Pd(Ph₃P)4 / dimethylformamide / 30 h / 80 °C

2.1: 55 percent / HCO₂H / Raney-Ni / 10 h / 110 °C

3.1: 90 percent / NH₂OH*HCl; Na₂CO₃ / H₂O / 2 h / 20 °C

4.1: NCS; HCl / dimethylformamide / 0.5 h / 20 °C

5.1: KN(TMS)2 / diethyl ether / 1 h / 20 °C

5.2: acetonitrile / 3 h / 20 °C

6.1: 95 percent / aq. LiOH / tetrahydrofuran / 12 h / 20 °C

With hydrogenchloride; lithium hydroxide; N-chloro-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; formic acid; hydroxylamine hydrochloride; potassium hexamethylsilazane; sodium carbonate; nickel; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.05.055