N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin

Base Information

• Chemical Name: N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin
• CAS No.: 14636-12-5
• Molecular Formula: C52H74N16O15S2
• Molecular Weight: 1227.39
• Hs Code.: 3504009000
• Mol file: 14636-12-5.mol

Synonyms:(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]-13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(1S)-5-amino-1-(carbamoylmethylcarbamoyl)pentyl]pyrrolidine-2-carboxamide;N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin;Glypressin;Terlipressin Acetate;Remestyp;Thymosin α1 Acetate;Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (disulfide bridge 4:9);Glycylpressin;

Chemical Property of N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin

Chemical Property:

• Appearance/Colour: White powder
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.664
• Boiling Point: 1824 °C at 760 mmHg
• PKA: 9.90±0.15(Predicted)
• Flash Point: 1056.9 °C
• PSA: 563.45000
• Density: 1.46 g/cm³
• LogP: 0.05740
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%min ^*data from raw suppliers

Terlipressin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Terlipressin acetate is a novel synthetic long-acting vasopressin preparation. It is a kind of prodrug, which is inactive by itself. After the action of aminopeptidase in the body, after removing the three glycyl residues at its N-terminus, it slowly "releases" the active lysine vasopressin. Therefore, terlipressin acts as a reservoir that releases lysine vasopressin at a steady rate.
• Uses: N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin is used norepinephrine-resistant septic shock and hepatorenal syndrome. N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin is also used in the treatment of acute variceal bleeding.
• Clinical Use: Treatment of bleeding oesophageal varices
• Drug interactions: Potentially hazardous interactions with other drugs None known