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| CAS No.: | 14636-12-5 |
|---|---|
| Name: | N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin |
| Molecular Structure: | |
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| Formula: | C52H74N16O15S2 |
| Molecular Weight: | 1227.39 |
| Synonyms: | (2S)-1-[(4R,7S,10S,13S,16S,19R)-19-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]-13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(1S)-5-amino-1-(carbamoylmethylcarbamoyl)pentyl]pyrrolidine-2-carboxamide;N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin;Glypressin;Terlipressin Acetate;Remestyp;Thymosin α1 Acetate;Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (disulfide bridge 4:9);Glycylpressin; |
| EINECS: | 238-680-8 |
| Density: | 1.46 g/cm3 |
| Boiling Point: | 1824 °C at 760 mmHg |
| Flash Point: | 1056.9 °C |
| Appearance: | White powder |
| PSA: | 563.45000 |
| LogP: | 0.05740 |
- 146368-07-23H-Indolium,1-ethyl-2,3,3-trimethyl-5-sulfo-, inner salt
- 146368-08-31-(5-carboxypentyl)-2,3,3-trimethyl-3H-indolium-5-sulfonate (IM OCS)
- 146368-09-43H-Indolium,1-ethyl-3,3-dimethyl-2-[2-(phenylamino)ethenyl]-5-sulfo-, inner salt
- 14636-95-4Propylmalonic acid
- 146370-52-7Benzene,1,4-bis(chloromethyl)-2-[(2-ethylhexyl)oxy]-5-methoxy-
- 146374-27-82-Propanesulfinamide,2-methyl-
- 146374-56-33(4H)-Quinazolineaceticacid, 5,6-dichloro-2-(cyanoamino)-, ethyl ester
- 14637-88-8Dysprosium,tris(2,4-pentanedionato-kO2,kO4)-, (OC-6-11)-
- 14638-18-7Butanedioic acid,1-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl]ester, calcium salt (2:1)
- 146381-87-52,4-Thiophenedicarboxylicacid, 5-[(2-chloroacetyl)amino]-3-methyl-, 2,4-diethyl ester
| Conditions | Yield |
|---|---|
| With blood serum of pregnant women In water at 37℃; for 1h; Kinetics; other pH; |
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Analytical Methods
Terlipressin is a synthetic analog of vasopressin and is used as a vasoactive drug in the management of hypotension. It is a prodrug, which is converted to (Lys8)- vasopressin after removal of the N-terminal triglycine in vivo. Terlipressin has a longer duration of action and a better safety profile than the parent compound.
Specification
1. Introduction of Terlipressin
Terlipressin, with the IUPAC Name of (2S)-1-[(1R,4S,7S,10S,13S,16R)-16-[[2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]acetyl]amino]-
4-(2-amino-2-oxoethyl)-7-(3-amino-3-oxopropyl)-10-benzyl-13-[(4-hydroxyphenyl)methyl]-3,6,9,12,15-pentaoxo-18,19-
dithia-2,5,8,11,14-pentazacycloicosane-1-carbonyl]-N-[(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-
2-yl]pyrrolidine-2-carboxamide, is one kind of white powder. This chemical belongs to the Product Categories which include Amino Acid Derivatives; Peptide.
2. Properties of Terlipressin
Terlipressin has the following datas: (1)H bond acceptors: 31; (2)H bond donors: 21; (3)Freely Rotating Bonds: 28; (4)Polar Surface Area: 350.65; (5)Index of Refraction: 1.664; (6)Molar Refractivity: 310.14 cm3; (7)Molar Volume: 835.7 cm3; (8)Surface Tension: 87.3 dyne/cm; (9)Density: 1.46 g/cm3; (10)Flash Point: 1056.9 °C; (11)Enthalpy of Vaporization: 306.02 kJ/mol; (12)Boiling Point: 1824 °C at 760 mmHg; (13)Vapour Pressure: 0 mmHg at 25°C.
3. Use and Preparation of Terlipressin
Terlipressin (CAS NO.14636-12-5) is used as a vasoactive drug in the management of hypotension. In addition, it is also used in bleeding esophageal varices.