Chemical Property of Triptorelin
Chemical Property:
- Appearance/Colour:powder
- PKA:9.82±0.15(Predicted)
- PSA：487.92000
- Density:1.52 g/cm3
- LogP:3.20000
- Storage Temp.:−20°C
- Solubility.:Aqueous Base (Slightly), Methanol (Very Slightly, Heated, Sonicated), Water (Sli
- Purity/Quality:
-
99% *data from raw suppliers
Triptorelin Acetate *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T
- Statements:
60
- Safety Statements:
53-22-36/37/39-45
- MSDS Files:
-
SDS file from LookChem
Useful:
-
Description
Decapeptyl is a modified (D-Trp6) LH-RH. Like recently marketed buserelin and
leuprolide (I), it is useful in achieving medical castration in the treatment of advanced prostate cancer.
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Uses
promoting ovulation Triptorelin is a GnRH agaonist shown to inhibit estradiol-induced cancer cell proliferation. [D-Trp6]-LH-RH (luteinizing hormone releasing hormone) has been used to study whether the (M. – X) region in electron capture dissociation provides information on amino acid composition of polypeptides. It is also used to study the effect of LH-RH on the production of progesterone (P), estradiol (E2) or human chorionic gonadotropin (hCG) by JEG-3 choriocarcinoma cells.
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Clinical Use
Triptorelin pamoate is another superagonist of GnRH, which like nafarelin acetate contains only
a single amino acid substitution (D-Trp6 for Gly6) when compared to the natural hormone. In the treatment of advanced prostate cancer, it is important to reduce serum
testosterone levels to very low levels, which can be achieved surgically by orchiectomy. When
this surgical method is unacceptable to the patient, an alternative approach is “chemical
castration,” which can be achieved by use of estrogen therapy, leuprolide,goserelin or histrelin acetates, and now, triptorelin pamoate. This product is available for IM
depot injection (monthly or every 3 months), wherein serum testosterone concentration drops to
a level generally seen in surgically castrated men.
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Drug interactions
Potentially hazardous interactions with other drugs
None known
