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Technology Process of Ziconotide

Ziconotide

Base Information
  • Chemical Name:Ziconotide
  • CAS No.:107452-89-1
  • Deprecated CAS:150770-63-1,148979-96-8,148979-97-9
  • Molecular Formula:C102H172N36O32S7
  • Molecular Weight:2639.13
  • Hs Code.:
  • European Community (EC) Number:686-412-7
  • UNII:7I64C51O16
  • ChEMBL ID:CHEMBL4594214
  • DSSTox Substance ID:DTXSID60883174
  • NCI Thesaurus Code:C1475
  • Pharos Ligand ID:3DCHD6M15VCV,8QG8M23F1W4M
  • RXCUI:68503
  • Wikipedia:Ziconotide
  • Mol file:107452-89-1.mol
Ziconotide

Synonyms:CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2;leconotide;omega-conopeptide MVIIA;omega-conotoxin M VIIA;omega-conotoxin MVIIA;omega-conotoxin MVIIA, Conus magus;Prialt;SNX 111;SNX-111;ziconotide

Suppliers and Price of Ziconotide
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • ZiconotidePolyacetate
  • 2.5mg
  • $ 3390.00
  • Sigma-Aldrich
  • ω-Conotoxin MVIIA ≥95% (HPLC)
  • 0.1 mg
  • $ 245.00
  • Sigma-Aldrich
  • ω-Conotoxin MVIIA ≥95% (HPLC)
  • .1mg
  • $ 236.00
  • Sigma-Aldrich
  • ω-Conotoxin MVIIA ≥95% (HPLC)
  • 0.5 mg
  • $ 885.00
  • Sigma-Aldrich
  • ω-Conotoxin MVIIA ≥95% (HPLC)
  • .5mg
  • $ 852.00
  • Biosynth Carbosynth
  • Omega-Conotoxin MVIIA
  • 500 ug
  • $ 600.00
Total 123 raw suppliers
Chemical Property of Ziconotide
Chemical Property:
  • Appearance/Colour:white powder 
  • PSA：1310.94000 
  • Density:1.60±0.1 g/cm3(Predicted) 
  • LogP:-1.73800 
  • Storage Temp.:−20°C 
  • XLogP3:-14
  • Hydrogen Bond Donor Count:42
  • Hydrogen Bond Acceptor Count:46
  • Rotatable Bond Count:40
  • Exact Mass:2638.1016905
  • Heavy Atom Count:177
  • Complexity:5480
Purity/Quality:

≥98% *data from raw suppliers

ZiconotidePolyacetate *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC1C(=O)NC(C(=O)NC2CSSCC3C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(CSSCC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NCC(=O)N1)CCCCN)CCCCN)N)C(=O)NC(C(=O)NCC(=O)NC(C(=O)N3)CO)C(C)O)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CO)CCCNC(=N)N)CC(C)C)CCSC)CC4=CC=C(C=C4)O)CC(=O)O)C(=O)N)CCCCN)CO)CCCNC(=N)N)CCCCN
  • Isomeric SMILES:C[C@H]1C(=O)N[C@H](C(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N1)CCCCN)CCCCN)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N3)CO)[C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)CO)CCCNC(=N)N)CC(C)C)CCSC)CC4=CC=C(C=C4)O)CC(=O)O)C(=O)N)CCCCN)CO)CCCNC(=N)N)CCCCN
  • Recent ClinicalTrials:OP2C : Prialt? Observatory in Clinical Practice
  • Recent EU Clinical Trials:Evaluation of a Structured Algorithm for Intrathecal Bolus Doses of Ziconotide(Prialt?) - The Swedish Ziconotide Bolus Study
  • Uses Ligand for binding studies of voltage sensitive calcium channels. Ziconotide, the peptide toxin of the Conus magus (cone snail) is a selective antagonist of N-type voltage sensitive calcium channels (VSCC). Blocks neurotransmitter release by preventing depolarization-induced calcium influx. Used as a ligand for binding studies of voltage sensitive calcium channels. Analgesic; neuroprotective.
Refernces

Synthesis of a non-peptide analogue of omega-conotoxin MVIIA

10.1016/S0040-4039(98)01657-8

The research aims to develop an efficient synthesis of a peptidomimetic compound that mimics the key amino acids of omega-conotoxin MVIIA, a potent analgesic peptide from the cone shell Conus magus. The purpose of this study is to create a low molecular weight, non-peptide antagonist of N-type neuronal calcium channels, which could potentially serve as a more practical alternative to the peptide for treating severe neuropathic pain, given the high potency and non-addictive nature of omega-conotoxin MVIIA. The researchers employed a dendroid approach to attach side-chain mimetics of the key amino acids (Lys-2, Arg-10, Leu-11, Tyr-13, and Arg-21) to a dendritic backbone, using phloroglucinol as a core unit and introducing aryl ether linkages through Williamson and Mitsunobu etherifications. The synthesis resulted in the desired peptide analogue with high yield and confirmed its structure through NMR spectroscopy and HRMS analysis. The study concludes that the synthesized compound provides a versatile platform for further molecular modeling, organic synthesis, and biological screening, with ongoing biological evaluation to assess its potential as a therapeutic agent.

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