L-Ala-L-Pro

Base Information

• Chemical Name: L-Ala-L-Pro
• CAS No.: 13485-59-1
• Molecular Formula: C8H14N2O3
• Molecular Weight: 186.211
• Hs Code.: 29339900
• Mol file: 13485-59-1.mol

Synonyms:L-Ala-L-Pro;AP zwitterion;Ala-Pro zwitterion;alanylproline zwitterion;L-Ala-L-Pro zwitterion;L-alanyl-L-proline zwitterion;CHEBI:155848;(2S)-1-[(2S)-2-azaniumylpropanoyl]pyrrolidine-2-carboxylate

Chemical Property of L-Ala-L-Pro

Chemical Property:

• Vapor Pressure: 1.2E-07mmHg at 25°C
• Melting Point: 170-178 °C
• Refractive Index: -112 ° (C=2, H2O)
• Boiling Point: 403.8 °C at 760 mmHg
• PKA: 3.19±0.20(Predicted)
• Flash Point: 198 °C
• PSA: 83.63000
• Density: 1.294 g/cm³
• LogP: 0.04740
• Storage Temp.: −20°C
• Solubility.: Methanol (Slightly), Water (Slightly)
• Water Solubility.: within almost transparency
• XLogP3: -2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 186.10044231
• Heavy Atom Count: 13
• Complexity: 224

Purity/Quality:

99.9% ^*data from raw suppliers

L-Alanyl-L-proline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C(=O)N1CCCC1C(=O)[O-])[NH3+]
• Isomeric SMILES: C[C@@H](C(=O)N1CCC[C@H]1C(=O)[O-])[NH3+]
• Uses: L-Alanyl-L-proline is a dipeptide that contains a sterically constrained proline, a well-known turn inducer in proteins.

Technology Process of L-Ala-L-Pro

There total 21 articles about L-Ala-L-Pro which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-benzyloxycarbonyl-L-alanyl-L-proline (21027-01-0) → L-alanyl-L-proline (13485-59-1)

Guidance literature:

With acetic acid; 10% palladium on active carbon; In methanol; for 2h;

DOI:10.1007/BF02219346

Reference yield: 72.0%

→ L-alanyl-L-proline (13485-59-1) + 1,3-Dicyclohexylurea (2387-23-7)

Guidance literature:

Reference yield:

1-((Ξ)-2-bromo-propionyl)-L-proline (115116-62-6) → 1-Ξ-alanyl-L-proline (3918-95-4,13485-59-1,60643-20-1,61430-12-4,90410-25-6,112243-92-2)

Guidance literature:

With ammonium hydroxide;

upstream raw materials:

L-proline

1-((Ξ)-2-bromo-propionyl)-L-proline

N-benzyloxycarbonyl-L-alanyl-L-proline

(S)-1-((S)-2-Phosphonoamino-propionyl)-pyrrolidine-2-carboxylic acid

Downstream raw materials:

(S)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-1-cyano-3-phenyl-propylamino)-propionyl]-pyrrolidine-2-carboxylic acid

N-<1-carboxamido-2-<(tert-butoxycarbonyl)amino>-3-phenylpropyl>-Ala-Pro-OCH3

ethanolN--Ala-Pro-OEt

N-methyl>-Ala-Pro