(2S)-1-((2S)-2-(((1R)-1-(Ethoxycarbonyl)-3-phenylpropyl)amino)propanoyl)pyrrolidine-2-carboxylic acid

Base Information

Chemical Name:(2S)-1-((2S)-2-(((1R)-1-(Ethoxycarbonyl)-3-phenylpropyl)amino)propanoyl)pyrrolidine-2-carboxylic acid
CAS No.:76420-74-1
Molecular Formula:C₂₀H₂₈N₂O₅
Molecular Weight:376.453
Hs Code.:
UNII:S7IJ7OBG9V
DSSTox Substance ID:DTXSID601181936
Wikidata:Q27166441
ChEMBL ID:CHEMBL400363

Synonyms:Kinfil;Enalapril impurity A;(S, S, R)-Enalapril;UNII-S7IJ7OBG9V;S7IJ7OBG9V;76420-74-1;Enalapril maleate impurity A;Enalapril maleate impurity A [EP];Enalapril maleate specified impurity A [EP];(2S)-1-((2S)-2-(((1R)-1-(Ethoxycarbonyl)-3-phenylpropyl)amino)propanoyl)pyrrolidine-2-carboxylic acid;L-Proline, N-((1R)-1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl-;(2S)-1-[(2S)-2-[[(2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid;SCHEMBL97;MLS003882560;CHEMBL400363;CHEBI:94620;DTXSID601181936;MK421;MFCD00865774;AKOS015961139;NCGC00188953-01;AC-13212;PD070292;SMR002533626;LS-177215;ENALAPRIL MALEATE IMPURITY A [EP IMPURITY];Q27166441;N-[(1R)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline;(S)-1-((S)-2-((S)-1-ethoxy-1-oxo-4-phenylbutan-2-ylamino)propanoyl)pyrrolidine-2-carboxylic acid

Suppliers and Price of (2S)-1-((2S)-2-(((1R)-1-(Ethoxycarbonyl)-3-phenylpropyl)amino)propanoyl)pyrrolidine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (2S)-1-((2S)-2-(((1R)-1-(Ethoxycarbonyl)-3-phenylpropyl)amino)propanoyl)pyrrolidine-2-carboxylic acid

Chemical Property:

XLogP3:-0.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:376.19982200
Heavy Atom Count:27
Complexity:519

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CCCC2C(=O)O
Isomeric SMILES:CCOC(=O)[C@@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)O

Technology Process of (2S)-1-((2S)-2-(((1R)-1-(Ethoxycarbonyl)-3-phenylpropyl)amino)propanoyl)pyrrolidine-2-carboxylic acid

There total 1 articles about (2S)-1-((2S)-2-(((1R)-1-(Ethoxycarbonyl)-3-phenylpropyl)amino)propanoyl)pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64920-29-2
2-oxo-4-phenylbutanoic acid ethyl ester

: 13485-59-1
L-alanyl-L-proline

: 75847-73-3
enalapril

: 76420-74-1
enalapril

Guidance literature:: nickel; Product distribution; var. catalysts and reducing agents, diastereomeric ratio;
DOI:10.1021/jo00239a029

Reference yield: 94.0%

: 76420-74-1
enalapril

: (R)-2-((3S,8aS)-3-Methyl-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-4-phenyl-butyric acid ethyl ester

Guidance literature:: In xylene; for 5h; Heating;
DOI:10.1016/S0022-2860(98)00399-8

Reference yield:

: 76420-74-1
enalapril

: (R)-2-((3S,8aR)-3-Methyl-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-4-phenyl-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / xylene / 5 h / Heating

2: tetramethylammonium hydroxide / ethanol / 2 h

With tetramethyl ammoniumhydroxide; In ethanol; xylene;
DOI:10.1016/S0022-2860(98)00399-8