4,7-bis[4-(tert-butyldimethylsilyloxy)phenyl]-5,6-bis(methoxymethoxy)-2,2-dimethylbenzo[d][1,3]dioxole

Base Information

Chemical Name:4,7-bis[4-(tert-butyldimethylsilyloxy)phenyl]-5,6-bis(methoxymethoxy)-2,2-dimethylbenzo[d][1,3]dioxole
CAS No.:1377948-87-2
Molecular Formula:C₃₇H₅₄O₈Si₂
Molecular Weight:683.002
Hs Code.:

Synonyms:4,7-bis[4-(tert-butyldimethylsilyloxy)phenyl]-5,6-bis(methoxymethoxy)-2,2-dimethylbenzo[d][1,3]dioxole

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Chemical Property of 4,7-bis[4-(tert-butyldimethylsilyloxy)phenyl]-5,6-bis(methoxymethoxy)-2,2-dimethylbenzo[d][1,3]dioxole

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Technology Process of 4,7-bis[4-(tert-butyldimethylsilyloxy)phenyl]-5,6-bis(methoxymethoxy)-2,2-dimethylbenzo[d][1,3]dioxole

There total 5 articles about 4,7-bis[4-(tert-butyldimethylsilyloxy)phenyl]-5,6-bis(methoxymethoxy)-2,2-dimethylbenzo[d][1,3]dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1192062-29-5
2,4,6-tris[4-(tert-butyldimethylsilanyloxy)phenyl]cyclotriboroxane

: 1377948-89-4
4,7-dibromo-5,6-bis-(methoxymethoxy)-2,2-dimethylbenzo[d][1,3]dioxole

: 1377948-87-2
4,7-bis[4-(tert-butyldimethylsilyloxy)phenyl]-5,6-bis(methoxymethoxy)-2,2-dimethylbenzo[d][1,3]dioxole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 24 ℃; for 2h; Reflux;
DOI:10.1021/jo300565s

Reference yield:

: 1377948-94-1
5,6-bis(methoxymethoxy)-2,2-dimethylbenzo[d][1,3]dioxole

: 1377948-87-2
4,7-bis[4-(tert-butyldimethylsilyloxy)phenyl]-5,6-bis(methoxymethoxy)-2,2-dimethylbenzo[d][1,3]dioxole

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 °C

1.2: 1 h / 0 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 2 h / 24 °C / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; hexane; water; 2.1: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jo300565s

Reference yield:

: 1377948-91-8
2,2-dimethylbenzo[d][1,3]dioxole-5,6-dione

: 1377948-87-2
4,7-bis[4-(tert-butyldimethylsilyloxy)phenyl]-5,6-bis(methoxymethoxy)-2,2-dimethylbenzo[d][1,3]dioxole

Guidance literature:: Multi-step reaction with 4 steps

1.1: platinum(IV) oxide; hydrogen / tetrahydrofuran / 2 h / 24 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

2.2: 20 h / 0 - 24 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 °C

3.2: 1 h / 0 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 2 h / 24 °C / Reflux

With platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; hydrogen; sodium hydride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; hexane; water; N,N-dimethyl-formamide; mineral oil; 4.1: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jo300565s