spiro(6-ethoxycarbonyl-7-methyl-2-oxo-5-phenyl-1H-2,3,4,5-tetrahydroazepine-4,2'-indan-1',3'-dione)

Base Information

• Chemical Name: spiro(6-ethoxycarbonyl-7-methyl-2-oxo-5-phenyl-1H-2,3,4,5-tetrahydroazepine-4,2'-indan-1',3'-dione)
• CAS No.: 1025801-79-9
• Molecular Formula: C₂₄H₂₁NO₅
• Molecular Weight: 403.434

Synonyms:spiro(6-ethoxycarbonyl-7-methyl-2-oxo-5-phenyl-1H-2,3,4,5-tetrahydroazepine-4,2'-indan-1',3'-dione)

Chemical Property of spiro(6-ethoxycarbonyl-7-methyl-2-oxo-5-phenyl-1H-2,3,4,5-tetrahydroazepine-4,2'-indan-1',3'-dione)

Chemical Property:

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Technology Process of spiro(6-ethoxycarbonyl-7-methyl-2-oxo-5-phenyl-1H-2,3,4,5-tetrahydroazepine-4,2'-indan-1',3'-dione)

There total 2 articles about spiro(6-ethoxycarbonyl-7-methyl-2-oxo-5-phenyl-1H-2,3,4,5-tetrahydroazepine-4,2'-indan-1',3'-dione) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

ethyl 4a-ethoxycarbonylmethyl-5-oxo-4-phenyl-4a,5-dihydro-4H-indeno[1,2-b]pyridine-3-carboxylate → ethyl α-acetyl-β-(2,3-dihydro-1,3-dioxo-2-(ethoxycarbonyl)methyl-1H-inden-2-yl)-β-phenylpropionate (1025801-83-5) + spiro(6-ethoxycarbonyl)-2-hydroxy-7-methyl-5-phenyl-2,3,4,5-tetrahydroazepine-4,2'-indan-1',3'-dione (1025801-79-9) + spiro(6-ethoxycarbonyl-7-methyl-2-oxo-5-phenyl-1H-2,3,4,5-tetrahydroazepine-4,2'-indan-1',3'-dione) (1025801-79-9) + ethyl (1,3-dioxoindan-2-yl)acetate (86489-63-6)

Guidance literature:

With hydrogenchloride; In methanol; for 5h; Heating;

DOI:10.1007/s10593-007-0032-y

Reference yield: 42.0%

ethyl 4a-ethoxycarbonylmethyl-5-oxo-4-phenyl-4a,5-dihydro-4H-indeno[1,2-b]pyridine-3-carboxylate → ethyl α-acetyl-β-(2,3-dihydro-1,3-dioxo-2-(ethoxycarbonyl)methyl-1H-inden-2-yl)-β-phenylpropionate (1025801-83-5) + spiro(6-ethoxycarbonyl)-2-hydroxy-7-methyl-5-phenyl-2,3,4,5-tetrahydroazepine-4,2'-indan-1',3'-dione (1025801-79-9) + spiro(6-ethoxycarbonyl-7-methyl-2-oxo-5-phenyl-1H-2,3,4,5-tetrahydroazepine-4,2'-indan-1',3'-dione) (1025801-79-9) + ethyl (1,3-dioxoindan-2-yl)acetate (86489-63-6)

Guidance literature:

With hydrogenchloride; In methanol; for 5h; Heating;

DOI:10.1007/s10593-007-0032-y

Reference yield: 65.0%

spiro(6-ethoxycarbonyl-7-methyl-2-oxo-5-phenyl-1H-2,3,4,5-tetrahydroazepine-4,2'-indan-1',3'-dione) (1025801-79-9) + methyl iodide (74-88-4) → spiro(6-ethoxycarbonyl-1,7-dimethyl-2-hydroxy-5-phenyl-1H-2,3,4,5-tetrahydroazepine-4,2'-indan-1',3'-dione) (1025801-86-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1007/s10593-007-0032-y

Downstream raw materials:

spiro(6-ethoxycarbonyl-1,7-dimethyl-2-hydroxy-5-phenyl-1H-2,3,4,5-tetrahydroazepine-4,2'-indan-1',3'-dione)

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