(2S,3S)-3-methyl-3-<4'-(trimethylsilyl)phenyl>oxiranemethanol

Base Information

• Chemical Name: (2S,3S)-3-methyl-3-<4'-(trimethylsilyl)phenyl>oxiranemethanol
• CAS No.: 151774-90-2
• Molecular Formula: C₁₃H₂₀O₂Si
• Molecular Weight: 236.386
• Mol file: 151774-90-2.mol

Synonyms:(2S,3S)-3-methyl-3-<4'-(trimethylsilyl)phenyl>oxiranemethanol

Chemical Property of (2S,3S)-3-methyl-3-<4'-(trimethylsilyl)phenyl>oxiranemethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S)-3-methyl-3-<4'-(trimethylsilyl)phenyl>oxiranemethanol

There total 3 articles about (2S,3S)-3-methyl-3-<4'-(trimethylsilyl)phenyl>oxiranemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-<4'-(trimethylsilyl)phenyl>-2-buten-1-ol → (2S,3S)-3-methyl-3-<4'-(trimethylsilyl)phenyl>oxiranemethanol (151774-90-2)

Guidance literature:

With titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate;

DOI:10.1016/S0957-4166(00)80334-1

Reference yield:

4-(trimethylsilyl)acetophenone (17983-61-8) → (2S,3S)-3-methyl-3-<4'-(trimethylsilyl)phenyl>oxiranemethanol (151774-90-2)

Guidance literature:

Multi-step reaction with 3 steps

1: EtOLi

2: LiAlH₄

3: 70 percent / (+)-diisopropyl tartrate, Ti(OPrⁱ)4, t-BuOOH

With titanium(IV) isopropylate; tert.-butylhydroperoxide; lithium aluminium tetrahydride; L-(+)-diisopropyl tartrate; lithium ethoxide;

DOI:10.1016/S0957-4166(00)80334-1

Reference yield:

ethyl 3-<4'-(trimethylsilyl)phenyl>-2-butenoate → (2S,3S)-3-methyl-3-<4'-(trimethylsilyl)phenyl>oxiranemethanol (151774-90-2)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄

2: 70 percent / (+)-diisopropyl tartrate, Ti(OPrⁱ)4, t-BuOOH

With titanium(IV) isopropylate; tert.-butylhydroperoxide; lithium aluminium tetrahydride; L-(+)-diisopropyl tartrate;

DOI:10.1016/S0957-4166(00)80334-1

upstream raw materials:

4-(trimethylsilyl)acetophenone

Downstream raw materials:

(2R,3S)-3-<4'-(trimethylsilyl)phenyl>butane-1,2-diol

(S)-ibuprofen

(R)-ibuprofene

(2R,3S)-3-(4'-bromophenyl)butane-1,2-diol