ethyl 2-methyl-2-({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)propanoate

Base Information

Chemical Name:ethyl 2-methyl-2-({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)propanoate
CAS No.:638214-22-9
Molecular Formula:C₃₀H₃₄F₃NO₄
Molecular Weight:529.599
Hs Code.:

Synonyms:ethyl 2-methyl-2-({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)propanoate

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Chemical Property of ethyl 2-methyl-2-({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)propanoate

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Technology Process of ethyl 2-methyl-2-({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)propanoate

There total 10 articles about ethyl 2-methyl-2-({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 328919-32-0
2-(4-Hydroxy-2-methyl-phenoxy)-2-methyl-propionic Acid Ethyl Ester

: 638214-09-2
1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}-1-pentanol

: 638214-22-9
ethyl 2-methyl-2-({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)propanoate

Guidance literature:: 1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}-1-pentanol; With tributylphosphine; di-isopropyl azodicarboxylate; In tetrahydrofuran; at 0 ℃; for 0.333333h;

2-(4-Hydroxy-2-methyl-phenoxy)-2-methyl-propionic Acid Ethyl Ester; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 638214-22-9
ethyl 2-methyl-2-({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 20 h / 100 °C

2.1: tributylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.33 h / 0 °C

2.2: 16 h / 0 - 20 °C

With tributylphosphine; di-isopropyl azodicarboxylate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1.1: Suzuki Coupling / 2.1: Mitsunobu reaction;

Reference yield:

: 626-05-1
2,6-Dibromopyridine

: 638214-22-9
ethyl 2-methyl-2-({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 °C

1.2: 0.27 h / -78 °C

2.1: manganese(IV) oxide / chloroform / 7.5 h

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 17.5 h / Heating / reflux

4.1: sodium tetrahydroborate / tetrahydrofuran; water / 2.58 - 2.67 h / 0 °C

5.1: tributylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.33 h / 0 °C

5.2: 16 h / 0 - 20 °C

With manganese(IV) oxide; sodium tetrahydroborate; n-butyllithium; tributylphosphine; di-isopropyl azodicarboxylate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexanes; 1,2-dimethoxyethane; chloroform; water; 3.1: Suzuki Coupling / 5.1: Mitsunobu reaction;