2-methyl-2-({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)propanoic acid

Base Information

Chemical Name:2-methyl-2-({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)propanoic acid
CAS No.:638215-29-9
Molecular Formula:C₂₈H₃₀F₃NO₄
Molecular Weight:501.546
Hs Code.:

Synonyms:2-methyl-2-({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)propanoic acid

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Chemical Property of 2-methyl-2-({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)propanoic acid

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Technology Process of 2-methyl-2-({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)propanoic acid

There total 11 articles about 2-methyl-2-({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 638214-22-9
ethyl 2-methyl-2-({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)propanoate

: 638215-29-9
2-methyl-2-({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)propanoic acid

Guidance literature:: ethyl 2-methyl-2-({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)propanoate; With sodium hydroxide; In tetrahydrofuran; water; at 80 ℃; for 40h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 638215-29-9
2-methyl-2-({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 20 h / 100 °C

2.1: tributylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.33 h / 0 °C

2.2: 16 h / 0 - 20 °C

3.1: sodium hydroxide / tetrahydrofuran; water / 40 h / 80 °C

With sodium hydroxide; tributylphosphine; di-isopropyl azodicarboxylate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1.1: Suzuki Coupling / 2.1: Mitsunobu reaction;

Reference yield:

: 626-05-1
2,6-Dibromopyridine

: 638215-29-9
2-methyl-2-({2-methyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 °C

1.2: 0.27 h / -78 °C

2.1: manganese(IV) oxide / chloroform / 7.5 h

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 17.5 h / Heating / reflux

4.1: sodium tetrahydroborate / tetrahydrofuran; water / 2.58 - 2.67 h / 0 °C

5.1: tributylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.33 h / 0 °C

5.2: 16 h / 0 - 20 °C

6.1: sodium hydroxide / tetrahydrofuran; water / 40 h / 80 °C

With manganese(IV) oxide; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; tributylphosphine; di-isopropyl azodicarboxylate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexanes; 1,2-dimethoxyethane; chloroform; water; 3.1: Suzuki Coupling / 5.1: Mitsunobu reaction;