tert-butyl 4-(pyridin-3-yloxy)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(pyridin-3-yloxy)piperidine-1-carboxylate
• CAS No.: 310881-47-1
• Molecular Formula: C₁₅H₂₂N₂O₃
• Molecular Weight: 278.351
• Mol file: 310881-47-1.mol

Synonyms:3-(N-(tert-butoxycarbonyl)-4-piperidinyloxy)pyridine;1-tert-Butoxycarbonyl-4-(3-pyridyloxy)piperidine;1-tert-Butoxycarbonyl-4-(pyridin-3-yloxy)piperidine;tert-butyl 4-(3-pyridyloxy)-1-piperidinecarboxylate;tert-butyl 4-(pyridin-3-yloxy)piperidine-1-carboxylate;

Chemical Property of tert-butyl 4-(pyridin-3-yloxy)piperidine-1-carboxylate

Chemical Property:

• Boiling Point: 391.4±32.0 °C(Predicted)
• PKA: 4.63±0.10(Predicted)
• PSA: 51.66000
• Density: 1.125±0.06 g/cm3(Predicted)
• LogP: 2.79780

Purity/Quality:

99% ^*data from raw suppliers

4-(PYRIDIN-3-YLOXY)PIPERIDINE-1-CARBOXYLIC ACID-TERT-BUTYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-(pyridin-3-yloxy)piperidine-1-carboxylate

There total 7 articles about tert-butyl 4-(pyridin-3-yloxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

→ 1,1-dimethylethyl 4-(3'-pyridinyloxy)-1-piperidinecarboxylate (310881-47-1)

Guidance literature:

Reference yield: 69.0%

3-HYDROXYPYRIDINE (109-00-2) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 1,1-dimethylethyl 4-(3'-pyridinyloxy)-1-piperidinecarboxylate (310881-47-1)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 70 ℃;

DOI:10.1016/j.tetlet.2006.11.161

Reference yield: 46.0%

pyridin-4-ol (626-64-2,157061-69-3) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 1,1-dimethylethyl 4-(3'-pyridinyloxy)-1-piperidinecarboxylate (310881-47-1)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 - 55 ℃;

upstream raw materials:

3-HYDROXYPYRIDINE

t-butyl 4-hydroxy piperidine-1-carboxylate

4-HYDROXYPIPERIDINE

di-tert-butyl dicarbonate

Downstream raw materials:

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(3-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-acrylamide

3-(piperidin-4-yloxy)pyridine hydrochloride

3-((4-piperidinyl)oxy)pyridine