C₁₂H₁₇NO₂

Base Information

• Chemical Name: C₁₂H₁₇NO₂
• CAS No.: 1431854-83-9
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.272
• Mol file: 1431854-83-9.mol

Synonyms:C₁₂H₁₇NO₂

Chemical Property of C₁₂H₁₇NO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₇NO₂

There total 8 articles about C₁₂H₁₇NO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

C12H15N3O2 (1431854-82-8) → C12H17NO2 (1431854-83-9)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; for 10h;

DOI:10.1016/j.tetasy.2013.02.016

Reference yield:

3-Phenylpropenol (104-54-1) → C12H17NO2 (1431854-83-9)

Guidance literature:

Multi-step reaction with 8 steps

1.1: hexanoic acid / 17 h / 166 °C / Heating

2.1: potassium hydroxide / water; methanol / 1 h / Inert atmosphere; Reflux

3.1: Pseudomonas cepacia lipase / 24 h / 40 °C / Enzymatic reaction

4.1: ozone / dichloromethane / -78 °C

4.2: 0.5 h / -10 °C

5.1: sodium cyanoborohydride / ethyl acetate; acetic acid / 0.33 h / 20 °C

6.1: triethylamine / dichloromethane / 6 h / 0 - 20 °C

7.1: sodium azide; 18-crown-6 ether; 1,8-diazabicyclo[5.4.0]undec-7-ene; dmap / dichloromethane / 72 h / Reflux

8.1: palladium on activated charcoal; hydrogen / ethanol / 10 h

With dmap; sodium azide; Pseudomonas cepacia lipase; 18-crown-6 ether; palladium on activated charcoal; hydrogen; sodium cyanoborohydride; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; hexanoic acid; potassium hydroxide; In methanol; ethanol; dichloromethane; water; acetic acid; ethyl acetate; 1.1: |Claisen Condensation;

DOI:10.1016/j.tetasy.2013.02.016

Reference yield:

3-phenylpent-4-enoic acid (5703-57-1,132032-89-4) → C12H17NO2 (1431854-83-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: penicillium roqueforti lipase / toluene / 24 h / 40 °C / Inert atmosphere; Enzymatic reaction

2.1: ozone / dichloromethane / -78 °C

2.2: 0.5 h / -10 °C

3.1: sodium cyanoborohydride / ethyl acetate; acetic acid / 0.33 h / 20 °C

4.1: triethylamine / dichloromethane / 6 h / 0 - 20 °C

5.1: sodium azide; 18-crown-6 ether; 1,8-diazabicyclo[5.4.0]undec-7-ene; dmap / dichloromethane / 72 h / Reflux

6.1: palladium on activated charcoal; hydrogen / ethanol / 10 h

With dmap; sodium azide; penicillium roqueforti lipase; 18-crown-6 ether; palladium on activated charcoal; hydrogen; sodium cyanoborohydride; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In ethanol; dichloromethane; acetic acid; ethyl acetate; toluene;

DOI:10.1016/j.tetasy.2013.02.016

upstream raw materials:

3-Phenylpropenol

(R)-(+)-3-phenyl-4-pentenoic acid ethyl ester

3-phenylpent-4-enoic acid

ethyl 3-phenyl-4-pentenoate

Downstream raw materials:

(S)-4-phenyl-1-tosylpyrrolidin-2-one

4-amino-(3S)-3-phenyl-butyric acid hydrochloride