17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(3',4'-dichloro)benzamido]morphinan

Base Information

Chemical Name:17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(3',4'-dichloro)benzamido]morphinan
CAS No.:1016258-89-1
Molecular Formula:C₂₇H₂₈Cl₂N₂O₄
Molecular Weight:515.436
Hs Code.:

Synonyms:17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(3',4'-dichloro)benzamido]morphinan

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(3',4'-dichloro)benzamido]morphinan

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Technology Process of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(3',4'-dichloro)benzamido]morphinan

There total 3 articles about 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(3',4'-dichloro)benzamido]morphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 67025-97-2
6β-naltrexamine

: 3024-72-4
3,4-dichlorobenzoyl chloride

: 1016258-89-1
17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(3',4'-dichloro)benzamido]morphinan

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm701060e

Reference yield: 92.0%

: 1016258-89-1
17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(3',4'-dichloro)benzamido]morphinan

Guidance literature:

Reference yield:

: 51-44-5
3,4-dichlorbenzoic acid

: 67025-97-2
6β-naltrexamine

: 1016258-89-1
17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(3',4'-dichloro)benzamido]morphinan

Guidance literature:: 3,4-dichlorbenzoic acid; 6β-naltrexamine; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

With potassium carbonate; In methanol; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2009.07.069