(1R,2S)-trans-2-[2'-(β-naphthyl)-2'-propyl]cyclohexyl N^α-benzoyl-N^ε-(2''-trimethylsilyl)ethanesulfonyl-N^ε-4'''-methoxybenzyl-L-α-vinyllysinate

Base Information

• Chemical Name: (1R,2S)-trans-2-[2'-(β-naphthyl)-2'-propyl]cyclohexyl N^α-benzoyl-N^ε-(2''-trimethylsilyl)ethanesulfonyl-N^ε-4'''-methoxybenzyl-L-α-vinyllysinate
• CAS No.: 925451-40-7
• Molecular Formula: C₄₇H₆₂N₂O₆SSi
• Molecular Weight: 811.171

Synonyms:(1R,2S)-trans-2-[2'-(β-naphthyl)-2'-propyl]cyclohexyl N^α-benzoyl-N^ε-(2''-trimethylsilyl)ethanesulfonyl-N^ε-4'''-methoxybenzyl-L-α-vinyllysinate

Chemical Property of (1R,2S)-trans-2-[2'-(β-naphthyl)-2'-propyl]cyclohexyl N^α-benzoyl-N^ε-(2''-trimethylsilyl)ethanesulfonyl-N^ε-4'''-methoxybenzyl-L-α-vinyllysinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S)-trans-2-[2'-(β-naphthyl)-2'-propyl]cyclohexyl N^α-benzoyl-N^ε-(2''-trimethylsilyl)ethanesulfonyl-N^ε-4'''-methoxybenzyl-L-α-vinyllysinate

There total 7 articles about (1R,2S)-trans-2-[2'-(β-naphthyl)-2'-propyl]cyclohexyl N^α-benzoyl-N^ε-(2''-trimethylsilyl)ethanesulfonyl-N^ε-4'''-methoxybenzyl-L-α-vinyllysinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2'-trimethylsilyl)ethanesulfonyl-N-4''-iodobutyl-4-methoxybenzylamine (925451-38-3) + 2-benzoylamino-but-2-enoic acid 2-(1-methyl-1-naphthalen-2-yl-ethyl)-cyclohexyl ester → (1R,2S)-trans-2-[2'-(β-naphthyl)-2'-propyl]cyclohexyl Nα-benzoyl-Nε-(2''-trimethylsilyl)ethanesulfonyl-Nε-4'''-methoxybenzyl-L-α-vinyllysinate (925451-40-7) + (1R,2S)-trans-2-[2-(β-naphthyl)-2-propyl]cyclohexyl Nα-benzoyl-Nε-(2-trimethylsilyl)ethanesulfonyl-Nε-4-methoxybenzyl-D-α-vinyllysinate

Guidance literature:

2-benzoylamino-but-2-enoic acid 2-(1-methyl-1-naphthalen-2-yl-ethyl)-cyclohexyl ester; With n-butyllithium; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; at -78 ℃;

N-(2'-trimethylsilyl)ethanesulfonyl-N-4''-iodobutyl-4-methoxybenzylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; at -78 ℃; for 5h; Title compound not separated from byproducts;

DOI:10.1021/ja067240k

Reference yield:

N-(2'-trimethylsilyl)ethanesulfonyl-4-methoxybenzylamine (925451-33-8) → (1R,2S)-trans-2-[2'-(β-naphthyl)-2'-propyl]cyclohexyl Nα-benzoyl-Nε-(2''-trimethylsilyl)ethanesulfonyl-Nε-4'''-methoxybenzyl-L-α-vinyllysinate (925451-40-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C

1.2: 77 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 91 percent / sodium iodide / acetone / 14 h / 50 °C / Heating

3.1: LDA; n-BuLi / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / -78 °C

3.2: tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / 5 h / -78 °C

With n-butyllithium; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; acetone;

DOI:10.1021/ja067240k

Reference yield:

N-(2'-trimethylsilyl)ethanesulfonyl-N-(4''-chlorobutyl)-4-methoxybenzylamine (925451-36-1) → (1R,2S)-trans-2-[2'-(β-naphthyl)-2'-propyl]cyclohexyl Nα-benzoyl-Nε-(2''-trimethylsilyl)ethanesulfonyl-Nε-4'''-methoxybenzyl-L-α-vinyllysinate (925451-40-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 91 percent / sodium iodide / acetone / 14 h / 50 °C / Heating

2.1: LDA; n-BuLi / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / -78 °C

2.2: tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / 5 h / -78 °C

With n-butyllithium; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; acetone;

DOI:10.1021/ja067240k

upstream raw materials:

N-(2'-trimethylsilyl)ethanesulfonyl-N-4''-iodobutyl-4-methoxybenzylamine

(1R,2S)-trans-2-[2'-(β-naphthyl)-2'-propyl]cyclohexyl N^α-benzoyl-N^ε-4''-methoxybenzyl-L-α-vinyllysinate

2-trimethylsilanyl-ethanesulfonyl chloride

N-(2'-trimethylsilyl)ethanesulfonyl-4-methoxybenzylamine

Downstream raw materials:

methyl N^α-benzoyl-N^ε-(2''-trimethylsilyl)ethanesulfonyl-L-α-(2'Z-fluorovinyl)lysinate

methyl N^α-benzoyl-N^ε-(2'-trimethylsilyl)ethanesulfonyl-N^ε-4''-methoxybenzyl-L-α-formyllysinate

methyl N^α-benzoyl-N^ε-(2'-trimethylsilyl)ethanesulfonyl-N^ε-4''-methoxybenzyl-L-α-vinyllysinate

N^α-benzoyl-N^ε-(2'-trimethylsilyl)ethanesulfonyl-N^ε-4''-methoxybenzyl-L-α-vinyllysine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 925451-40-7 (1R,2S)-trans-2-[2'-(β-naphthyl)-2'-propyl]cyclohexyl N^α-benzoyl-N^ε-(2''-trimethylsilyl)ethanesulfonyl-N^ε-4'''-methoxybenzyl-L-α-vinyllysinate

Send

Send

Metric Ton KG G Pound L ML

Send

Send