4-(4-tert-butoxycarbonylamino-benzoylamino)-1-methyl-1H-imidazole-2-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-(4-tert-butoxycarbonylamino-benzoylamino)-1-methyl-1H-imidazole-2-carboxylic acid ethyl ester
• CAS No.: 292070-18-9
• Molecular Formula: C₁₉H₂₄N₄O₅
• Molecular Weight: 388.423
• Mol file: 292070-18-9.mol

Synonyms:4-(4-tert-butoxycarbonylamino-benzoylamino)-1-methyl-1H-imidazole-2-carboxylic acid ethyl ester

Chemical Property of 4-(4-tert-butoxycarbonylamino-benzoylamino)-1-methyl-1H-imidazole-2-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(4-tert-butoxycarbonylamino-benzoylamino)-1-methyl-1H-imidazole-2-carboxylic acid ethyl ester

There total 1 articles about 4-(4-tert-butoxycarbonylamino-benzoylamino)-1-methyl-1H-imidazole-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(N-tert-butoxycarbonyl)aminobenzoic acid (66493-39-8) + ethyl 4-amino-1-methylimidazole-2-carboxylate (128293-62-9) → 4-(4-tert-butoxycarbonylamino-benzoylamino)-1-methyl-1H-imidazole-2-carboxylic acid ethyl ester (292070-18-9)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 25 ℃;

DOI:10.1021/ja994192d

Reference yield:

4-(4-tert-butoxycarbonylamino-benzoylamino)-1-methyl-1H-imidazole-2-carboxylic acid ethyl ester (292070-18-9) → 4-(4-amino-benzoylamino)-1-methyl-1H-imidazole-2-carboxylic acid ethyl ester; hydrochloride

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 25 ℃; for 2h;

DOI:10.1016/S0968-0896(00)00137-1

Reference yield:

4-(4-tert-butoxycarbonylamino-benzoylamino)-1-methyl-1H-imidazole-2-carboxylic acid ethyl ester (292070-18-9) → 4-{4-[(5-tert-butoxycarbonylamino-benzo[b]thiophene-2-carbonyl)-amino]-benzoylamino}-1-methyl-1H-imidazole-2-carboxylic acid ethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 4.0 N HCl / ethyl acetate / 2 h / 25 °C

2: EDCI; DMAP / dimethylformamide / 16 h / 25 °C

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethyl acetate; N,N-dimethyl-formamide; 1: BOC-deprotection / 2: Acylation;

DOI:10.1016/S0968-0896(00)00137-1

upstream raw materials:

4-(N-tert-butoxycarbonyl)aminobenzoic acid

ethyl 4-amino-1-methylimidazole-2-carboxylate