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66493-39-8

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66493-39-8 Usage

Chemical Properties

Light brown powder

Uses

4-(N-tert-Butoxycarbonyl)aminobenzoic Acid is the tert-Butyloxycarbonyl group protected derivative of 4-Aminobenzoic Acid (A591500), an widely distributed B complex factor in nature.

Check Digit Verification of cas no

The CAS Registry Mumber 66493-39-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,4,9 and 3 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 66493-39:
(7*6)+(6*6)+(5*4)+(4*9)+(3*3)+(2*3)+(1*9)=158
158 % 10 = 8
So 66493-39-8 is a valid CAS Registry Number.
InChI:InChI=1/C12H15NO4/c1-12(2,3)17-11(16)13-9-6-4-8(5-7-9)10(14)15/h4-7H,1-3H3,(H,13,16)(H,14,15)/p-1

66493-39-8 Well-known Company Product Price

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  • (Code)Product description
  • CAS number
  • Packaging
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  • Alfa Aesar

  • (L18531)  4-(Boc-amino)benzoic acid, 97%   

  • 66493-39-8

  • 1g

  • 354.0CNY

  • Detail
  • Alfa Aesar

  • (L18531)  4-(Boc-amino)benzoic acid, 97%   

  • 66493-39-8

  • 5g

  • 910.0CNY

  • Detail
  • Aldrich

  • (15299)  Boc-4-Abz-OH  ≥98.0% (T)

  • 66493-39-8

  • 15299-5G

  • 1,254.24CNY

  • Detail
  • Aldrich

  • (15299)  Boc-4-Abz-OH  ≥98.0% (T)

  • 66493-39-8

  • 15299-50G

  • 6,943.95CNY

  • Detail

66493-39-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[(2-methylpropan-2-yl)oxycarbonylamino]benzoic acid

1.2 Other means of identification

Product number -
Other names 4-(Boc-amino)benzoic Acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:66493-39-8 SDS

66493-39-8Relevant articles and documents

Design, synthesis and evaluation of novel indole-2-carboxamides for growth inhibition of Mycobacterium tuberculosis and paediatric brain tumour cells

Alsayed, Shahinda S. R.,Lun, Shichun,Bailey, Anders W.,Suri, Amreena,Huang, Chiang-Ching,Mocerino, Mauro,Payne, Alan,Sredni, Simone Treiger,Bishai, William R.,Gunosewoyo, Hendra

, p. 15497 - 15511 (2021)

The omnipresent threat of tuberculosis (TB) and the scant treatment options thereof necessitate the development of new antitubercular agents, preferably working via a novel mechanism of action distinct from the current drugs. Various studies identified th

Thiamine hydrochloride as a recyclable organocatalyst for the efficient and chemoselective N-tert-butyloxycarbonylation of amines

Ingale, Ajit P.,Garad, Dnyaneshwar N.,Ukale, Dattatraya,Thorat, Nitin M.,Shinde, Sandeep V.

supporting information, p. 3791 - 3804 (2021/11/04)

Thiamin hydrochloride promoted highly efficient and ecofriendly approach has been described for the chemoselective N-tert-butyloxycarbonylation of amines under solvent-free conditions at ambient temperature. The demonstrated approach has been applicable for the N-Boc protection of variety of aliphatic, aryl, heteroaryl amines. The chemoselective protection of amino group occurs in chiral amines and amino alcohol without racemization in high yield. Thiamin hydrochloride is stable, economical, easy to handle and environmentally friendly.

Antiglioma Activity of Aryl and Amido-Aryl Acetamidine Derivatives Targeting iNOS: Synthesis and Biological Evaluation

Maccallini, Cristina,Arias, Fabio,Gallorini, Marialucia,Amoia, Pasquale,Ammazzalorso, Alessandra,De Filippis, Barbara,Fantacuzzi, Marialuigia,Giampietro, Letizia,Cataldi, Amelia,Camacho, María Encarnación,Amoroso, Rosa

supporting information, p. 1470 - 1475 (2020/07/31)

Nitric oxide is an important inflammation mediator with a recognized role in the development of different cancers. Gliomas are primary tumors of the central nervous system with poor prognosis, and the expression of the inducible nitric oxide synthase correlates with the degree of malignancy, changes in vascular reactivity, and neo-angiogenesis. Therefore, targeting the nitric oxide biosynthesis appears as a potential strategy to impair glioma progression. In the present work a set of aryl and amido-aryl acetamidine derivatives were synthesized to obtain new potent and selective inducible nitric oxide synthase inhibitors with improved physicochemical parameters with respect to the previously published molecules. Compound 17 emerged as the most promising inhibitor and was evaluated on C6 rat glioma cell line, showing antiproliferative effects and high selectivity over astrocytes.

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