Amikacin sulfate

Base Information

• Chemical Name: Amikacin sulfate
• CAS No.: 39831-55-5
• Deprecated CAS: 37357-52-1
• Molecular Formula: C22H43N5O13^.2(H2SO4)
• Molecular Weight: 781.768
• Hs Code.: 29419000
• European Community (EC) Number: 254-648-6
• UNII: N6M33094FD
• DSSTox Substance ID: DTXSID601045247
• Wikidata: Q27105754
• NCI Thesaurus Code: C230
• RXCUI: 643
• Metabolomics Workbench ID: 52958
• ChEMBL ID: CHEMBL4208954
• Mol file: 39831-55-5.mol

Synonyms:A.M.K;Amikacin;Amikacin Sulfate;Amikacina Medical;Amikacina Normon;Amikafur;Amikalem;Amikason's;Amikayect;Amikin;Amiklin;Amukin;BB K 8;BB K8;BB-K 8;BB-K8;BBK 8;BBK8;Biclin;Biklin;Gamikal;Kanbine;Medical, Amikacina;Normon, Amikacina;Oprad;Sulfate, Amikacin;Yectamid

Chemical Property of Amikacin sulfate

Chemical Property:

• Appearance/Colour: white
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 220-230 °C
• Boiling Point: 981.8 °C at 760 mmHg
• Flash Point: 547.6 °C
• PSA: 497.90000
• LogP: -4.37610
• Storage Temp.: 2-8°C
• Solubility.: H2O: 50 mg/mL, clear, colorless
• Water Solubility.: Soluble in water at 50mg/ml with warming
• Hydrogen Bond Donor Count: 17
• Hydrogen Bond Acceptor Count: 25
• Rotatable Bond Count: 10
• Exact Mass: 781.22049587
• Heavy Atom Count: 50
• Complexity: 900

Purity/Quality:

99% ,99.9%, ^*data from raw suppliers

Amikacin disulfate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

Useful:

• Canonical SMILES: C1C(C(C(C(C1NC(=O)C(CCN)O)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(C(C(C(O3)CN)O)O)O)N.OS(=O)(=O)O.OS(=O)(=O)O
• Isomeric SMILES: C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1NC(=O)[C@H](CCN)O)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CN)O)O)O)N.OS(=O)(=O)O.OS(=O)(=O)O
• Uses: Semisynthetic aminoglycoside antibiotic derived from Kanamycin A. Antibacterial. Analgesic Amikacin disulfate is used as an aminoglycoside antibiotic derived from Kanamycin A, used for treating infections with multidrug resistant Gram negative bacteria such as Pseudomonas aeruginosa, Acinetobacter, and Enterobacter. It is commonly used in the treatment of drug-resistant mycobacteria. It is used to study organism-directed delivery of antibiotics as well as drug resistance.
• Therapeutic Function: Antibacterial

Technology Process of Amikacin sulfate

There total 1 articles about Amikacin sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.5%

amikacin (37517-28-5) → amikacin sulfate (39831-55-5)

Guidance literature:

With sulfuric acid; In ethanol; water; at 10 ℃; for 6h; Temperature;

Reference yield: 94.0%

carbenicillin disodium salt (4800-94-6,27025-51-0,32420-30-7,36912-57-9,83059-64-7,83113-57-9) + amikacin sulfate (39831-55-5,56086-43-2,110660-84-9,149022-22-0) → C56H75N9O25S2(4-)*H2O4S*4Na(1+)

Guidance literature:

In water; at 25 ℃; for 72h;

DOI:10.1021/jm00155a004

Reference yield: 29.0%

amikacin sulfate (39831-55-5) → 3-C-azido amikacin (1448168-07-7)

Guidance literature:

With imidazole-1-sulfonyl azide hydrochloride; In water; at 20 ℃; for 40h; pH=7; regioselective reaction;

DOI:10.1002/chem.201300912

upstream raw materials:

amikacin

Downstream raw materials:

amikacin

3-C-azido amikacin

Refernces