(2S,4S,5R)-2-(isobutyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid 2-(tert-butyl) ester 4-[(1R,2S,5R)-5-methyl-2-(isopropyl)cyclohexyl] ester hydrochloride

Base Information

• Chemical Name: (2S,4S,5R)-2-(isobutyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid 2-(tert-butyl) ester 4-[(1R,2S,5R)-5-methyl-2-(isopropyl)cyclohexyl] ester hydrochloride
• CAS No.: 687636-82-4
• Molecular Formula: C₂₇H₄₄N₂O₄S*ClH
• Molecular Weight: 529.184

Synonyms:(2S,4S,5R)-2-(isobutyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid 2-(tert-butyl) ester 4-[(1R,2S,5R)-5-methyl-2-(isopropyl)cyclohexyl] ester hydrochloride

Chemical Property of (2S,4S,5R)-2-(isobutyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid 2-(tert-butyl) ester 4-[(1R,2S,5R)-5-methyl-2-(isopropyl)cyclohexyl] ester hydrochloride

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Technology Process of (2S,4S,5R)-2-(isobutyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid 2-(tert-butyl) ester 4-[(1R,2S,5R)-5-methyl-2-(isopropyl)cyclohexyl] ester hydrochloride

There total 1 articles about (2S,4S,5R)-2-(isobutyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid 2-(tert-butyl) ester 4-[(1R,2S,5R)-5-methyl-2-(isopropyl)cyclohexyl] ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,4S,5R)-2-(isobutyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylicacid 2-(tert-butyl) ester 4-[(1R,2S,5R)-5-methyl-2-(isopropyl)cyclohexyl] ester → (2S,4S,5R)-2-(isobutyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid 2-(tert-butyl) ester 4-[(1R,2S,5R)-5-methyl-2-(isopropyl)cyclohexyl] ester hydrochloride (687636-82-4)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 0 ℃;

Reference yield:

(2S,4S,5R)-2-(isobutyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid 2-(tert-butyl) ester 4-[(1R,2S,5R)-5-methyl-2-(isopropyl)cyclohexyl] ester hydrochloride (687636-82-4) + 3-methoxy-4-tert-butylbenzoyl chloride (35291-92-0) → (2S,4S,5R)-2-isobutyl-1-(3-methoxy-4-tert-butylbenzoyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid 2-(tert-butyl) ester 4-[(1R,2S,5R)-5-methyl-2-(isopropyl)cyclohexyl] ester (687636-83-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 18h;

Downstream raw materials:

(2S,4S,5R)-2-isobutyl-1-(3-methoxy-4-tert-butylbenzoyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid 2-(tert-butyl) ester 4-[(1R,2S,5R)-5-methyl-2-(isopropyl)cyclohexyl] ester

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