3-(4-nitrophenyl)-5-[(2-oxopyrrolidin-1-carbonyl)amino]isothiazol-4-carboxylic acid amide

Base Information

Chemical Name:3-(4-nitrophenyl)-5-[(2-oxopyrrolidin-1-carbonyl)amino]isothiazol-4-carboxylic acid amide
CAS No.:1446246-84-9
Molecular Formula:C₁₅H₁₃N₅O₅S
Molecular Weight:375.365
Hs Code.:

Synonyms:3-(4-nitrophenyl)-5-[(2-oxopyrrolidin-1-carbonyl)amino]isothiazol-4-carboxylic acid amide

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Chemical Property of 3-(4-nitrophenyl)-5-[(2-oxopyrrolidin-1-carbonyl)amino]isothiazol-4-carboxylic acid amide

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Technology Process of 3-(4-nitrophenyl)-5-[(2-oxopyrrolidin-1-carbonyl)amino]isothiazol-4-carboxylic acid amide

There total 7 articles about 3-(4-nitrophenyl)-5-[(2-oxopyrrolidin-1-carbonyl)amino]isothiazol-4-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1446247-82-0
methyl 4-[({[4-cyano-3-(4-nitrophenyl)isothiazol-5-yl]amino}carbonyl)amino]butanoate

: 1446246-84-9
3-(4-nitrophenyl)-5-[(2-oxopyrrolidin-1-carbonyl)amino]isothiazol-4-carboxylic acid amide

Guidance literature:: methyl 4-[({[4-cyano-3-(4-nitrophenyl)isothiazol-5-yl]amino}carbonyl)amino]butanoate; With sulfuric acid; at 45 ℃; for 1.83333h;

With water; Cooling with ice;

Reference yield:

: 605661-26-5
2-[amino(4-nitrophenyl)methylene]malononitrile

: 1446246-84-9
3-(4-nitrophenyl)-5-[(2-oxopyrrolidin-1-carbonyl)amino]isothiazol-4-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: O,O-Diethyl hydrogen phosphorodithioate / ethanol; water / 100 °C / Inert atmosphere

2.1: dihydrogen peroxide / ethanol / 22 h / Inert atmosphere

3.1: potassium carbonate / tetrahydrofuran; dimethyl sulfoxide / 0.25 h / 20 °C

3.2: 20 °C

4.1: sulfuric acid / 1.83 h / 45 °C

4.2: Cooling with ice

With sulfuric acid; dihydrogen peroxide; potassium carbonate; O,O-Diethyl hydrogen phosphorodithioate; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide;

Reference yield:

: 909028-96-2
3-amino-3-(4-nitrophenyl)-2-thioformamidoacrylonitrile

: 1446246-84-9
3-(4-nitrophenyl)-5-[(2-oxopyrrolidin-1-carbonyl)amino]isothiazol-4-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: dihydrogen peroxide / ethanol / 22 h / Inert atmosphere

2.1: potassium carbonate / tetrahydrofuran; dimethyl sulfoxide / 0.25 h / 20 °C

2.2: 20 °C

3.1: sulfuric acid / 1.83 h / 45 °C

3.2: Cooling with ice

With sulfuric acid; dihydrogen peroxide; potassium carbonate; In tetrahydrofuran; ethanol; dimethyl sulfoxide;