4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)-7-((1,1-dioxidothiomorpholino)methyl)quinoline-3-carboxamide

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Chemical Name:4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)-7-((1,1-dioxidothiomorpholino)methyl)quinoline-3-carboxamide
CAS No.:1445787-17-6
Molecular Formula:C₂₈H₃₂F₃N₅O₅S₂
Molecular Weight:639.72
Hs Code.:

Synonyms:4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)-7-((1,1-dioxidothiomorpholino)methyl)quinoline-3-carboxamide

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Chemical Property of 4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)-7-((1,1-dioxidothiomorpholino)methyl)quinoline-3-carboxamide

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Technology Process of 4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)-7-((1,1-dioxidothiomorpholino)methyl)quinoline-3-carboxamide

There total 11 articles about 4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)-7-((1,1-dioxidothiomorpholino)methyl)quinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 77-77-0
Divinyl sulfone

: 1445790-09-9
7-(aminomethyl)-4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)quinoline-3-carboxamide

: 1445787-17-6
4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)-7-((1,1-dioxidothiomorpholino)methyl)quinoline-3-carboxamide

Guidance literature:: In ethanol; at 20 ℃; for 15h;

Reference yield:

: 89490-05-1,21190-87-4
cyclohex-1-enylboronic acid

: 1445787-17-6
4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)-7-((1,1-dioxidothiomorpholino)methyl)quinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 110 °C / Inert atmosphere; Microwave irradiation

2.1: pyridine / ethanol / 0.5 h / 110 °C

2.2: 0.67 h / 110 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C

4.1: hydrogen; acetic acid; palladium 10% on activated carbon / 4 h / 2068.65 - 2585.81 Torr

5.1: acetic acid / 16 h / 20 °C

6.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 120 - 150 °C / Microwave irradiation

7.1: Raney nickel / methanol / 6 h / 20 °C

8.1: ethanol / 15 h / 20 °C

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(tri-t-butylphosphine)palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1445789-97-8
3',5'-dinitro-2,3,4,5-tetrahydro-1,1'-biphenyl

: 1445787-17-6
4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)-7-((1,1-dioxidothiomorpholino)methyl)quinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / ethanol / 0.5 h / 110 °C

1.2: 0.67 h / 110 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C

3.1: hydrogen; acetic acid; palladium 10% on activated carbon / 4 h / 2068.65 - 2585.81 Torr

4.1: acetic acid / 16 h / 20 °C

5.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 120 - 150 °C / Microwave irradiation

6.1: Raney nickel / methanol / 6 h / 20 °C

7.1: ethanol / 15 h / 20 °C

With pyridine; bis(tri-t-butylphosphine)palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;