7-(aminomethyl)-4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)quinoline-3-carboxamide

Base Information

Chemical Name:7-(aminomethyl)-4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)quinoline-3-carboxamide
CAS No.:1445790-09-9
Molecular Formula:C₂₄H₂₆F₃N₅O₃S
Molecular Weight:521.563
Hs Code.:

Synonyms:7-(aminomethyl)-4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)quinoline-3-carboxamide

Suppliers and Price of 7-(aminomethyl)-4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)quinoline-3-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-(aminomethyl)-4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)quinoline-3-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 7-(aminomethyl)-4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)quinoline-3-carboxamide

There total 10 articles about 7-(aminomethyl)-4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)quinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445790-05-5
7-cyano-4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)quinoline-3-carboxamide

: 1445790-09-9
7-(aminomethyl)-4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)quinoline-3-carboxamide

Guidance literature:: With Raney nickel; In methanol; at 20 ℃; for 6h;

Reference yield:

: 1445789-97-8
3',5'-dinitro-2,3,4,5-tetrahydro-1,1'-biphenyl

: 1445790-09-9
7-(aminomethyl)-4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)quinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / ethanol / 0.5 h / 110 °C

1.2: 0.67 h / 110 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C

3.1: hydrogen; acetic acid; palladium 10% on activated carbon / 4 h / 2068.65 - 2585.81 Torr

4.1: acetic acid / 16 h / 20 °C

5.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 120 - 150 °C / Microwave irradiation

6.1: Raney nickel / methanol / 6 h / 20 °C

With pyridine; bis(tri-t-butylphosphine)palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 18242-39-2
3,5-dinitrobromobenzene

: 1445790-09-9
7-(aminomethyl)-4-((3-cyclohexyl-5-(trifluoromethylsulfonamido)phenyl)amino)quinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 110 °C / Inert atmosphere; Microwave irradiation

2.1: pyridine / ethanol / 0.5 h / 110 °C

2.2: 0.67 h / 110 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C

4.1: hydrogen; acetic acid; palladium 10% on activated carbon / 4 h / 2068.65 - 2585.81 Torr

5.1: acetic acid / 16 h / 20 °C

6.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 120 - 150 °C / Microwave irradiation

7.1: Raney nickel / methanol / 6 h / 20 °C

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(tri-t-butylphosphine)palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;