(R)-5-(2-{2-[2-(2-{[(tert-butoxy)carbonyl]amino}acetamido)propanamido]-4-methoxyphenyl}-1,3-dithian-2-yl)pentanoic acid

Base Information

Chemical Name:(R)-5-(2-{2-[2-(2-{[(tert-butoxy)carbonyl]amino}acetamido)propanamido]-4-methoxyphenyl}-1,3-dithian-2-yl)pentanoic acid
CAS No.:1415336-45-6
Molecular Formula:C₂₆H₃₉N₃O₇S₂
Molecular Weight:569.744
Hs Code.:

Synonyms:(R)-5-(2-{2-[2-(2-{[(tert-butoxy)carbonyl]amino}acetamido)propanamido]-4-methoxyphenyl}-1,3-dithian-2-yl)pentanoic acid

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Chemical Property of (R)-5-(2-{2-[2-(2-{[(tert-butoxy)carbonyl]amino}acetamido)propanamido]-4-methoxyphenyl}-1,3-dithian-2-yl)pentanoic acid

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Technology Process of (R)-5-(2-{2-[2-(2-{[(tert-butoxy)carbonyl]amino}acetamido)propanamido]-4-methoxyphenyl}-1,3-dithian-2-yl)pentanoic acid

There total 8 articles about (R)-5-(2-{2-[2-(2-{[(tert-butoxy)carbonyl]amino}acetamido)propanamido]-4-methoxyphenyl}-1,3-dithian-2-yl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1415336-44-5
(R)-methyl 5-(2-{2-[2-(2-{[(tert-butoxy)carbonyl]amino}acetamido)propanamido]-4-methoxyphenyl}-1,3-dithian-2-yl)pentanoate

: 1415336-45-6
(R)-5-(2-{2-[2-(2-{[(tert-butoxy)carbonyl]amino}acetamido)propanamido]-4-methoxyphenyl}-1,3-dithian-2-yl)pentanoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ol303149k

Reference yield:

: 588-16-9
m-methoxyacetanilide

: 1415336-45-6
(R)-5-(2-{2-[2-(2-{[(tert-butoxy)carbonyl]amino}acetamido)propanamido]-4-methoxyphenyl}-1,3-dithian-2-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: palladium(II) trifluoroacetate / toluene / Inert atmosphere; Sealed tube

1.2: 24 h / 90 °C / Inert atmosphere

2.1: boron trifluoride diethyl etherate / dichloromethane / 16 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride / water / 4 h / 40 - 50 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / water; dichloromethane / 6 h / 20 °C / Inert atmosphere

5.1: piperidine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere

7.1: lithium hydroxide / methanol; water; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With piperidine; hydrogenchloride; palladium(II) trifluoroacetate; boron trifluoride diethyl etherate; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; toluene;
DOI:10.1021/ol303149k

Reference yield:

: 1415336-37-6
methyl 6-(2-acetamido-4-methoxyphenyl)-6-oxohexanoate

: 1415336-45-6
(R)-5-(2-{2-[2-(2-{[(tert-butoxy)carbonyl]amino}acetamido)propanamido]-4-methoxyphenyl}-1,3-dithian-2-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: boron trifluoride diethyl etherate / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: hydrogenchloride / water / 4 h / 40 - 50 °C / Inert atmosphere

3: sodium hydrogencarbonate / water; dichloromethane / 6 h / 20 °C / Inert atmosphere

4: piperidine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere

6: lithium hydroxide / methanol; water; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With piperidine; hydrogenchloride; boron trifluoride diethyl etherate; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/ol303149k