6'-(N,N-dimethylamino)-1'-tosyl-1'H-spiro[fluorene-9,4'-indeno[1,2-b]pyrrole]

Base Information

Chemical Name:6'-(N,N-dimethylamino)-1'-tosyl-1'H-spiro[fluorene-9,4'-indeno[1,2-b]pyrrole]
CAS No.:1291063-46-1
Molecular Formula:C₃₂H₂₆N₂O₂S
Molecular Weight:502.637
Hs Code.:

Synonyms:6'-(N,N-dimethylamino)-1'-tosyl-1'H-spiro[fluorene-9,4'-indeno[1,2-b]pyrrole]

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Chemical Property of 6'-(N,N-dimethylamino)-1'-tosyl-1'H-spiro[fluorene-9,4'-indeno[1,2-b]pyrrole]

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Technology Process of 6'-(N,N-dimethylamino)-1'-tosyl-1'H-spiro[fluorene-9,4'-indeno[1,2-b]pyrrole]

There total 4 articles about 6'-(N,N-dimethylamino)-1'-tosyl-1'H-spiro[fluorene-9,4'-indeno[1,2-b]pyrrole] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1291063-41-6
3-(9-(2-bromo-5-(dimethylamino)phenyl)-9H-fluoren-9-yl)-N-tosylpyrrole

: 1291063-46-1
6'-(N,N-dimethylamino)-1'-tosyl-1'H-spiro[fluorene-9,4'-indeno[1,2-b]pyrrole]

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 96h; Inert atmosphere;
DOI:10.1016/j.tet.2011.02.073

Reference yield:

: 1291063-37-0
9-(2-bromo-5-(dimethylamino)phenyl)-9H-fluoren-9-ol

: 1291063-46-1
6'-(N,N-dimethylamino)-1'-tosyl-1'H-spiro[fluorene-9,4'-indeno[1,2-b]pyrrole]

Guidance literature:: Multi-step reaction with 2 steps

1: aluminum (III) chloride / dichloromethane / 4 h / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; potassium carbonate / N,N-dimethyl-formamide / 96 h / 100 °C / Inert atmosphere

With aluminum (III) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; 1: Friedel Crafts alkylation;
DOI:10.1016/j.tet.2011.02.073

Reference yield:

: 1291063-32-5
4-bromo-3-iodo-N,N-dimethylaniline

: 1291063-46-1
6'-(N,N-dimethylamino)-1'-tosyl-1'H-spiro[fluorene-9,4'-indeno[1,2-b]pyrrole]

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropylmagnesium bromide / tetrahydrofuran / 4 h / -40 °C

1.2: 17 h / -40 - 20 °C

2.1: aluminum (III) chloride / dichloromethane / 4 h / 20 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; potassium carbonate / N,N-dimethyl-formamide / 96 h / 100 °C / Inert atmosphere

With aluminum (III) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; isopropylmagnesium bromide; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2.1: Friedel Crafts alkylation;
DOI:10.1016/j.tet.2011.02.073