1'-(4-(methoxycarbonyl)benzoyl)-6'-(N,N-dimethyl-amino)-1'H-spiro[fluorene-9,4'-indeno[1,2-b]pyrrole]

Base Information

Chemical Name:1'-(4-(methoxycarbonyl)benzoyl)-6'-(N,N-dimethyl-amino)-1'H-spiro[fluorene-9,4'-indeno[1,2-b]pyrrole]
CAS No.:1291063-52-9
Molecular Formula:C₃₄H₂₆N₂O₃
Molecular Weight:510.592
Hs Code.:

Synonyms:1'-(4-(methoxycarbonyl)benzoyl)-6'-(N,N-dimethyl-amino)-1'H-spiro[fluorene-9,4'-indeno[1,2-b]pyrrole]

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Chemical Property of 1'-(4-(methoxycarbonyl)benzoyl)-6'-(N,N-dimethyl-amino)-1'H-spiro[fluorene-9,4'-indeno[1,2-b]pyrrole]

Chemical Property:

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Technology Process of 1'-(4-(methoxycarbonyl)benzoyl)-6'-(N,N-dimethyl-amino)-1'H-spiro[fluorene-9,4'-indeno[1,2-b]pyrrole]

There total 6 articles about 1'-(4-(methoxycarbonyl)benzoyl)-6'-(N,N-dimethyl-amino)-1'H-spiro[fluorene-9,4'-indeno[1,2-b]pyrrole] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1291063-50-7
6'-(N,N-dimethylamino)-1'H-spiro[fluorene-9,4'-indeno-[1,2-b]pyrrole]

: 7377-26-6
4-Methoxycarbonylbenzoyl chloride

: 1291063-52-9
1'-(4-(methoxycarbonyl)benzoyl)-6'-(N,N-dimethyl-amino)-1'H-spiro[fluorene-9,4'-indeno[1,2-b]pyrrole]

Guidance literature:: In dichloromethane; at 40 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.tet.2011.02.073

Reference yield:

: 1291063-32-5
4-bromo-3-iodo-N,N-dimethylaniline

: 1291063-52-9
1'-(4-(methoxycarbonyl)benzoyl)-6'-(N,N-dimethyl-amino)-1'H-spiro[fluorene-9,4'-indeno[1,2-b]pyrrole]

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopropylmagnesium bromide / tetrahydrofuran / 4 h / -40 °C

1.2: 17 h / -40 - 20 °C

2.1: aluminum (III) chloride / dichloromethane / 4 h / 20 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; potassium carbonate / N,N-dimethyl-formamide / 96 h / 100 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 22 h / 65 °C

5.1: dichloromethane / 12 h / 40 °C / Inert atmosphere

With aluminum (III) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; tetrabutyl ammonium fluoride; isopropylmagnesium bromide; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2.1: Friedel Crafts alkylation;
DOI:10.1016/j.tet.2011.02.073

Reference yield:

: 1291063-46-1
6'-(N,N-dimethylamino)-1'-tosyl-1'H-spiro[fluorene-9,4'-indeno[1,2-b]pyrrole]

: 1291063-52-9
1'-(4-(methoxycarbonyl)benzoyl)-6'-(N,N-dimethyl-amino)-1'H-spiro[fluorene-9,4'-indeno[1,2-b]pyrrole]

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 22 h / 65 °C

2: dichloromethane / 12 h / 40 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2011.02.073