2-(bis(2-tert-butoxy-2-oxoethyl)amino)-3-(4-(2-chloroacetamido)phenyl)propanoic acid

Base Information

Chemical Name:2-(bis(2-tert-butoxy-2-oxoethyl)amino)-3-(4-(2-chloroacetamido)phenyl)propanoic acid
CAS No.:1619224-42-8
Molecular Formula:C₂₃H₃₃ClN₂O₇
Molecular Weight:484.977
Hs Code.:

Synonyms:2-(bis(2-tert-butoxy-2-oxoethyl)amino)-3-(4-(2-chloroacetamido)phenyl)propanoic acid

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Chemical Property of 2-(bis(2-tert-butoxy-2-oxoethyl)amino)-3-(4-(2-chloroacetamido)phenyl)propanoic acid

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Technology Process of 2-(bis(2-tert-butoxy-2-oxoethyl)amino)-3-(4-(2-chloroacetamido)phenyl)propanoic acid

There total 4 articles about 2-(bis(2-tert-butoxy-2-oxoethyl)amino)-3-(4-(2-chloroacetamido)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1619224-41-7
3-(4-aminophenyl)-2-(bis-tertbutoxycarbonylmethylamino)propionic acid

: 79-04-9
chloroacetyl chloride

: 1619224-42-8
2-(bis(2-tert-butoxy-2-oxoethyl)amino)-3-(4-(2-chloroacetamido)phenyl)propanoic acid

Guidance literature:: 3-(4-aminophenyl)-2-(bis-tertbutoxycarbonylmethylamino)propionic acid; With triethylamine; In acetone; at 0 ℃; for 0.25h; Inert atmosphere;

chloroacetyl chloride; In acetone; at 0 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.05.046

Reference yield:

: 949-99-5
4-nitro-3-phenyl-L-alanine

: 1619224-42-8
2-(bis(2-tert-butoxy-2-oxoethyl)amino)-3-(4-(2-chloroacetamido)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 0.5 h / Inert atmosphere

1.2: 18 h / Inert atmosphere; Reflux

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / Inert atmosphere

3.1: triethylamine / acetone / 0.25 h / 0 °C / Inert atmosphere

3.2: 0 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In ethanol; acetone; acetonitrile;
DOI:10.1016/j.ejmech.2014.05.046

Reference yield:

: 1619224-40-6
2-(bis-2-tert-butoxycarbonylmethylamino)-3-(4-nitrophenyl)propanoic acid

: 1619224-42-8
2-(bis(2-tert-butoxy-2-oxoethyl)amino)-3-(4-(2-chloroacetamido)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / Inert atmosphere

2.1: triethylamine / acetone / 0.25 h / 0 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; triethylamine; In ethanol; acetone;
DOI:10.1016/j.ejmech.2014.05.046