Ethyl 3-[3-(2-t-butoxycarbonylaminoethyl)-5-(1-imidazolylmethyl)phenyl]propanoate

Base Information

Chemical Name:Ethyl 3-[3-(2-t-butoxycarbonylaminoethyl)-5-(1-imidazolylmethyl)phenyl]propanoate
CAS No.:145691-91-4
Molecular Formula:C₂₂H₃₁N₃O₄
Molecular Weight:401.506
Hs Code.:

Synonyms:Ethyl 3-[3-(2-t-butoxycarbonylaminoethyl)-5-(1-imidazolylmethyl)phenyl]propanoate

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Chemical Property of Ethyl 3-[3-(2-t-butoxycarbonylaminoethyl)-5-(1-imidazolylmethyl)phenyl]propanoate

Chemical Property:

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Technology Process of Ethyl 3-[3-(2-t-butoxycarbonylaminoethyl)-5-(1-imidazolylmethyl)phenyl]propanoate

There total 8 articles about Ethyl 3-[3-(2-t-butoxycarbonylaminoethyl)-5-(1-imidazolylmethyl)phenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 145691-84-5
3-[3-(2-Ethoxycarbonylethyl)-5-(1-imidazolylmethyl)phenyl]propanoic acid

: 75-65-0
tert-butyl alcohol

: 145691-91-4
Ethyl 3-[3-(2-t-butoxycarbonylaminoethyl)-5-(1-imidazolylmethyl)phenyl]propanoate

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; for 18h; Heating;

Reference yield:

: 56990-02-4
3,5-dibromobenzaldehyde

: 145691-91-4
Ethyl 3-[3-(2-t-butoxycarbonylaminoethyl)-5-(1-imidazolylmethyl)phenyl]propanoate

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / NaBH₄ / methanol / 0 - 20 °C

2: 94 percent / Pd(OAc)2, tri-o-tolylphosphine, Et₃N / acetonitrile / 1 h / Heating

3: Et₃N / CH₂Cl₂ / 1 h / 0 °C

4: Na₂CO₃ / acetone / 10 h / Heating

5: 81 percent / HCO₂NH₄ / 10percent Pd/C / ethanol; tetrahydrofuran / 1 h / 60 °C

6: 41 percent / aq. NaOH / ethanol / 0.75 h / Heating

7: 40 percent / diphenyl phosphorazidate, Et₃N / 18 h / Heating

With palladium diacetate; sodium hydroxide; sodium tetrahydroborate; diphenyl phosphoryl azide; ammonium formate; sodium carbonate; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetone; acetonitrile;

Reference yield:

: 145691-59-4
(3,5-dibromophenyl)methanol

: 145691-91-4
Ethyl 3-[3-(2-t-butoxycarbonylaminoethyl)-5-(1-imidazolylmethyl)phenyl]propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / Pd(OAc)2, tri-o-tolylphosphine, Et₃N / acetonitrile / 1 h / Heating

2: Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: Na₂CO₃ / acetone / 10 h / Heating

4: 81 percent / HCO₂NH₄ / 10percent Pd/C / ethanol; tetrahydrofuran / 1 h / 60 °C

5: 41 percent / aq. NaOH / ethanol / 0.75 h / Heating

6: 40 percent / diphenyl phosphorazidate, Et₃N / 18 h / Heating

With palladium diacetate; sodium hydroxide; diphenyl phosphoryl azide; ammonium formate; sodium carbonate; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetone; acetonitrile;