Avermectin B1a aglycone

Base Information

• Chemical Name: Avermectin B1a aglycone
• CAS No.: 71828-14-3
• Molecular Formula: C₃₄H₄₈O₈
• Molecular Weight: 584.75
• Mol file: 71828-14-3.mol

Synonyms:avermectin B_1a aglycone

Chemical Property of Avermectin B1a aglycone

Chemical Property:

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

Avermectin B1a aglycone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Avermectin aglycone is an acid degradation product produced by hydrolysis of the disaccharide unit of avermectin. Avermectin aglycone is an inhibitor of nematode larval development, but is devoid of paralytic activity. Despite the importance of avermectin as an anthelmintic in animal health, there are few published reports of the biological activity or the levels of avermectin aglycone in animals or in the environment.

Technology Process of Avermectin B1a aglycone

There total 2 articles about Avermectin B1a aglycone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

avermectin B1a (65195-55-3) → avermectin B1a aglycone (71828-14-3) + avermectin B1a monosaccharide (71831-09-9)

Guidance literature:

With sulfuric acid; In isopropyl alcohol; at 20 ℃;

DOI:10.1021/ja065950k

Reference yield: 50.0%

avermectin B1a (65195-55-3) → avermectin B1a monosaccharide (71831-09-9) + avermectin B1a aglycon (71828-14-3)

Guidance literature:

With sulfuric acid; In tetrahydrofuran; water; at 18 ℃; for 24h;

DOI:10.1021/jo00342a023

Reference yield:

avermectin B1a aglycone (71828-14-3) → avermectin B1a (65195-55-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / imidazole / dimethylformamide / 3 h / 0 °C

2: 35 percent / 4A molecular sieves, silver trifluoromethanesulfonate / CH₂Cl₂; toluene / 0.33 h / Ambient temperature

3: 64 percent / pyridinium hydrofluoride / acetonitrile; pyridine / 30 h / Ambient temperature

With 1H-imidazole; 4 A molecular sieve; silver trifluoromethanesulfonate; pyridine hydrogenfluoride; In pyridine; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1021/ja00112a006

upstream raw materials:

avermectin B₁a

avermectin B_1a

Downstream raw materials:

avermectin B₁a