(S)-3-(4-(6-(1-(3-(2-(1H-tetrazol-1-yl)phenyl)propanamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoic acid

Base Information

Chemical Name:(S)-3-(4-(6-(1-(3-(2-(1H-tetrazol-1-yl)phenyl)propanamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoic acid
CAS No.:1187646-60-1
Molecular Formula:C₃₂H₃₀N₈O₅
Molecular Weight:606.641
Hs Code.:

Synonyms:(S)-3-(4-(6-(1-(3-(2-(1H-tetrazol-1-yl)phenyl)propanamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoic acid

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Chemical Property of (S)-3-(4-(6-(1-(3-(2-(1H-tetrazol-1-yl)phenyl)propanamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoic acid

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Technology Process of (S)-3-(4-(6-(1-(3-(2-(1H-tetrazol-1-yl)phenyl)propanamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoic acid

There total 3 articles about (S)-3-(4-(6-(1-(3-(2-(1H-tetrazol-1-yl)phenyl)propanamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.3%

: 1187646-50-9
(S,E)-3-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoic acid

: 1187646-60-1
(S)-3-(4-(6-(1-(3-(2-(1H-tetrazol-1-yl)phenyl)propanamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoic acid

Guidance literature:: With ammonia; hydrogen; palladium 10% on activated carbon; In methanol; water; for 4h;

Reference yield:

: 1187648-45-8
(S,E)-tert-butyl 3-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoate

: 1187646-60-1
(S)-3-(4-(6-(1-(3-(2-(1H-tetrazol-1-yl)phenyl)propanamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 0.75 h / 20 °C

2: ammonia; hydrogen / palladium 10% on activated carbon / methanol; water / 4 h

With ammonia; hydrogen; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; water;

Reference yield:

: 1187648-44-7
(S,E)-N-(1-(5-(4-aminophenyl)-6-chloropyridazin-3-yl)-2-phenylethyl)-3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamide

: 1187646-60-1
(S)-3-(4-(6-(1-(3-(2-(1H-tetrazol-1-yl)phenyl)propanamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / dichloromethane; toluene; acetonitrile / 0.5 h / 0 °C

1.2: 2.67 h / 0 - 20 °C

2.1: trifluoroacetic acid / 0.75 h / 20 °C

3.1: ammonia; hydrogen / palladium 10% on activated carbon / methanol; water / 4 h

With ammonia; hydrogen; sodium hydrogencarbonate; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; water; toluene; acetonitrile;