(S,E)-tert-butyl 3-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoate

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Chemical Name:(S,E)-tert-butyl 3-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoate
CAS No.:1187648-45-8
Molecular Formula:C₃₆H₃₄Cl₂N₈O₅
Molecular Weight:729.623
Hs Code.:

Synonyms:(S,E)-tert-butyl 3-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoate

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Chemical Property of (S,E)-tert-butyl 3-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoate

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Technology Process of (S,E)-tert-butyl 3-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoate

There total 1 articles about (S,E)-tert-butyl 3-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.2%

: 75-44-5
phosgene

: 59854-11-4
tert-butyl 3-hydroxypropanoate

: 1187648-44-7
(S,E)-N-(1-(5-(4-aminophenyl)-6-chloropyridazin-3-yl)-2-phenylethyl)-3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamide

: 1187648-45-8
(S,E)-tert-butyl 3-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoate

Guidance literature:: phosgene; (S,E)-N-(1-(5-(4-aminophenyl)-6-chloropyridazin-3-yl)-2-phenylethyl)-3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamide; With sodium hydrogencarbonate; In dichloromethane; toluene; acetonitrile; at 0 ℃; for 0.5h;

tert-butyl 3-hydroxypropanoate; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2.66667h;

Reference yield: 77.0%

: 1187648-45-8
(S,E)-tert-butyl 3-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoate

: 1187646-50-9
(S,E)-3-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoic acid

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 0.75h;

Reference yield:

: 1187648-45-8
(S,E)-tert-butyl 3-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoate

: 1187646-60-1
(S)-3-(4-(6-(1-(3-(2-(1H-tetrazol-1-yl)phenyl)propanamido)-2-phenylethyl)pyridazin-4-yl)phenylcarbamoyloxy)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 0.75 h / 20 °C

2: ammonia; hydrogen / palladium 10% on activated carbon / methanol; water / 4 h

With ammonia; hydrogen; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; water;