Ginsenoside Rb3

Base Information

• Chemical Name: Ginsenoside Rb3
• CAS No.: 68406-26-8
• Molecular Formula: C₅₃H₉₀O₂₂
• Molecular Weight: 1079.28
• Hs Code.: 29389090
• Mol file: 68406-26-8.mol

Synonyms:Dammarane,b-D-glucopyranoside deriv.;Gypenoside IV;

Chemical Property of Ginsenoside Rb3

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 193～195℃
• Refractive Index: 1.621
• Boiling Point: 1125.1 °C at 760 mmHg
• PKA: 12.85±0.70(Predicted)
• Flash Point: 634.2 °C
• PSA: 357.06000
• Density: 1.42 g/cm³
• LogP: -1.56350
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Slightly), Pyridine (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ginsenoside Rb3 ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ginsenoside Rb3 inhibits the upregulation of phospho-IκB-α and nuclear translocation of NF-κB subunit p65 induced by glucose deprivation then reperfusion.

Technology Process of Ginsenoside Rb3

There total 7 articles about Ginsenoside Rb3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C55H92O23 → ginsenoside Rb2 (11021-13-9,68406-26-8,82166-13-0,82166-14-1,146987-67-9)

Guidance literature:

With potassium hydroxide; In methanol; Further stages; Reflux;

DOI:10.1039/c3sc51479j

Reference yield:

(20S)-3-O-{β-D-6-O-[(E)-but-2-enoyl]glucopyranosyl-(1->2)-β-D-glucopyranosyl}-20-O-[α-L-arabinopyranosyl-(1->6)-β-D-glucopyranosyl]protopanaxadiol (1346522-90-4) → ginsenoside Rb2 (11021-13-9,68406-26-8,82166-13-0,82166-14-1,146987-67-9)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 12h;

DOI:10.1002/cbdv.201000196

Reference yield:

C79H114O35 → ginsenoside Rb2 (11021-13-9,68406-26-8,82166-13-0,82166-14-1,146987-67-9) + C53H90O22

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h; Heating;

DOI:10.1248/cpb.40.2458

upstream raw materials:

(20S)-3-O-{β-D-6-O-[(E)-but-2-enoyl]glucopyranosyl-(1->2)-β-D-glucopyranosyl}-20-O-[α-L-arabinopyranosyl-(1->6)-β-D-glucopyranosyl]protopanaxadiol

malonyl-ginsenoside Rb₂

Downstream raw materials:

ginsenoside Rk₃

protopanaxadiol

ginsenoside F₂

compound K

Refernces

• 1、 Zhu, Guo-Yuan,Li, Ying-Wei,Kwok-Po Hau, Desmond,Jiang, Zhi-Hong,Yu, Zhi-Ling,Fong, Wang-Fun. "Acylated protopanaxadiol-type ginsenosides from the root of Panax ginseng". experimental part. p. 1853 - 1863. Retrieved 2012/01/13.
• 2、 Karikura,Tanizawa,Hirata,Miyase,Takino. "Studies on absorption, distribution, excretion and metabolism of Ginseng saponins. VIII. Isotope labeling of ginsenoside Rb2". . p. 2458 - 2460. Retrieved 2007/10/02.