1-benzenesulfonyl-2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-vinyl]-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridine

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Chemical Name:1-benzenesulfonyl-2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-vinyl]-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridine
CAS No.:1312018-64-6
Molecular Formula:C₂₉H₃₀N₂O₅S₂
Molecular Weight:550.7
Hs Code.:

Synonyms:1-benzenesulfonyl-2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-vinyl]-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 1-benzenesulfonyl-2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-vinyl]-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridine

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Technology Process of 1-benzenesulfonyl-2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-vinyl]-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridine

There total 12 articles about 1-benzenesulfonyl-2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-vinyl]-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1312018-63-5
toluene-4-sulfonic acid 1-(benzenesulfonyl-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-cyclopentyl-vinyl ester

: 149104-88-1
4-methanesulphonylphenylboronic acid

: 1312018-64-6
1-benzenesulfonyl-2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-vinyl]-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; water; at 100 ℃; for 2h; Microwave irradiation;

Reference yield:

: 211308-80-4
2-amino-3-iodo-5-nicotinic methyl ester

: 1312018-64-6
1-benzenesulfonyl-2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-vinyl]-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 12 steps

1.1: N-ethyl-N,N-diisopropylamine; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 0 - 25 °C

2.1: pyridine / dichloromethane / 12 h / 0 - 25 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 25 °C / Reflux

4.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C

4.2: 12.25 h / 0 - 25 °C

5.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 - 20 °C

6.1: thionyl chloride / dichloromethane / 2 h / 0 °C

7.1: methanol / 12 h / 20 °C

8.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C

8.2: 12.25 h / 0 - 25 °C

9.1: n-butyllithium / hexane; tetrahydrofuran / 0.08 h / -78 °C

9.2: 1 h / -78 °C

10.1: Dess-Martin periodane / dichloromethane / 1 h / 25 °C

11.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

11.2: 1.5 h / -78 °C

12.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 2 h / 100 °C / Microwave irradiation

With pyridine; copper(l) iodide; n-butyllithium; thionyl chloride; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; diisobutylaluminium hydride; sodium carbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hexamethyldisilazane; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 849067-96-5
1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester

: 1312018-64-6
1-benzenesulfonyl-2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-vinyl]-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C

1.2: 12.25 h / 0 - 25 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 - 20 °C

3.1: thionyl chloride / dichloromethane / 2 h / 0 °C

4.1: methanol / 12 h / 20 °C

5.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C

5.2: 12.25 h / 0 - 25 °C

6.1: n-butyllithium / hexane; tetrahydrofuran / 0.08 h / -78 °C

6.2: 1 h / -78 °C

7.1: Dess-Martin periodane / dichloromethane / 1 h / 25 °C

8.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

8.2: 1.5 h / -78 °C

9.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 2 h / 100 °C / Microwave irradiation

With n-butyllithium; thionyl chloride; tetrabutylammomium bromide; diisobutylaluminium hydride; sodium carbonate; Dess-Martin periodane; sodium hydroxide; lithium hexamethyldisilazane; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; water;