toluene-4-sulfonic acid 1-(benzenesulfonyl-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-cyclopentyl-vinyl ester

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Chemical Name:toluene-4-sulfonic acid 1-(benzenesulfonyl-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-cyclopentyl-vinyl ester
CAS No.:1312018-63-5
Molecular Formula:C₂₉H₃₀N₂O₆S₂
Molecular Weight:566.699
Hs Code.:

Synonyms:toluene-4-sulfonic acid 1-(benzenesulfonyl-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-cyclopentyl-vinyl ester

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Chemical Property of toluene-4-sulfonic acid 1-(benzenesulfonyl-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-cyclopentyl-vinyl ester

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Technology Process of toluene-4-sulfonic acid 1-(benzenesulfonyl-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-cyclopentyl-vinyl ester

There total 12 articles about toluene-4-sulfonic acid 1-(benzenesulfonyl-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-cyclopentyl-vinyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312018-62-4
1-(1-benzenesulfonyl-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-cyclopentyl-ethanone

: 4124-41-8
p-toluenesulfonylanhydride

: 1312018-63-5
toluene-4-sulfonic acid 1-(benzenesulfonyl-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-cyclopentyl-vinyl ester

Guidance literature:: 1-(1-benzenesulfonyl-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-cyclopentyl-ethanone; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

p-toluenesulfonylanhydride; In tetrahydrofuran; at -78 ℃; for 1.5h;

Reference yield:

: 211308-80-4
2-amino-3-iodo-5-nicotinic methyl ester

: 1312018-63-5
toluene-4-sulfonic acid 1-(benzenesulfonyl-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-cyclopentyl-vinyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: N-ethyl-N,N-diisopropylamine; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 0 - 25 °C

2.1: pyridine / dichloromethane / 12 h / 0 - 25 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 25 °C / Reflux

4.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C

4.2: 12.25 h / 0 - 25 °C

5.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 - 20 °C

6.1: thionyl chloride / dichloromethane / 2 h / 0 °C

7.1: methanol / 12 h / 20 °C

8.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C

8.2: 12.25 h / 0 - 25 °C

9.1: n-butyllithium / hexane; tetrahydrofuran / 0.08 h / -78 °C

9.2: 1 h / -78 °C

10.1: Dess-Martin periodane / dichloromethane / 1 h / 25 °C

11.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

11.2: 1.5 h / -78 °C

With pyridine; copper(l) iodide; n-butyllithium; thionyl chloride; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; diisobutylaluminium hydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 36052-24-1
methyl 6-aminonicotinoate

: 1312018-63-5
toluene-4-sulfonic acid 1-(benzenesulfonyl-5-methoxymethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-cyclopentyl-vinyl ester

Guidance literature:: Multi-step reaction with 12 steps

1.1: iodine; silver trifluoroacetate / methanol / 72 h / 25 °C

2.1: N-ethyl-N,N-diisopropylamine; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 0 - 25 °C

3.1: pyridine / dichloromethane / 12 h / 0 - 25 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 25 °C / Reflux

5.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C

5.2: 12.25 h / 0 - 25 °C

6.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 - 20 °C

7.1: thionyl chloride / dichloromethane / 2 h / 0 °C

8.1: methanol / 12 h / 20 °C

9.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C

9.2: 12.25 h / 0 - 25 °C

10.1: n-butyllithium / hexane; tetrahydrofuran / 0.08 h / -78 °C

10.2: 1 h / -78 °C

11.1: Dess-Martin periodane / dichloromethane / 1 h / 25 °C

12.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

12.2: 1.5 h / -78 °C

With pyridine; copper(l) iodide; n-butyllithium; thionyl chloride; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; iodine; silver trifluoroacetate; diisobutylaluminium hydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;