[1-Amino-5-(4-chloro-phenyl)-7,8,9,10-tetrahydro-6H-3-thia-4-aza-cyclohepta[e]inden-2-yl]-phenyl-methanone

Base Information

• Chemical Name: [1-Amino-5-(4-chloro-phenyl)-7,8,9,10-tetrahydro-6H-3-thia-4-aza-cyclohepta[e]inden-2-yl]-phenyl-methanone
• CAS No.: 144296-19-5
• Molecular Formula: C₂₅H₂₁ClN₂OS
• Molecular Weight: 432.974

Synonyms:[1-Amino-5-(4-chloro-phenyl)-7,8,9,10-tetrahydro-6H-3-thia-4-aza-cyclohepta[e]inden-2-yl]-phenyl-methanone

Chemical Property of [1-Amino-5-(4-chloro-phenyl)-7,8,9,10-tetrahydro-6H-3-thia-4-aza-cyclohepta[e]inden-2-yl]-phenyl-methanone

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Technology Process of [1-Amino-5-(4-chloro-phenyl)-7,8,9,10-tetrahydro-6H-3-thia-4-aza-cyclohepta[e]inden-2-yl]-phenyl-methanone

There total 3 articles about [1-Amino-5-(4-chloro-phenyl)-7,8,9,10-tetrahydro-6H-3-thia-4-aza-cyclohepta[e]inden-2-yl]-phenyl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-(4-Chloro-phenyl)-3-thioxo-3,5,6,7,8,9-hexahydro-2H-cyclohepta[c]pyridine-4-carbonitrile (129340-07-4) + α-bromoacetophenone (70-11-1) → [1-Amino-5-(4-chloro-phenyl)-7,8,9,10-tetrahydro-6H-3-thia-4-aza-cyclohepta[e]inden-2-yl]-phenyl-methanone (144296-19-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 - 60 ℃; for 3h;

DOI:10.1246/bcsj.65.2241

Reference yield:

cycloheptylidene-malononitrile (10394-94-2) → [1-Amino-5-(4-chloro-phenyl)-7,8,9,10-tetrahydro-6H-3-thia-4-aza-cyclohepta[e]inden-2-yl]-phenyl-methanone (144296-19-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / ethanol

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 - 60 °C

With potassium carbonate; triethylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1246/bcsj.65.2241

Reference yield:

2-cyano-3-(4-chlorophenyl)-prop-2-enethioamide (39145-33-0) → [1-Amino-5-(4-chloro-phenyl)-7,8,9,10-tetrahydro-6H-3-thia-4-aza-cyclohepta[e]inden-2-yl]-phenyl-methanone (144296-19-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / ethanol

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 - 60 °C

With potassium carbonate; triethylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1246/bcsj.65.2241

upstream raw materials:

1-(4-Chloro-phenyl)-3-thioxo-3,5,6,7,8,9-hexahydro-2H-cyclohepta[c]pyridine-4-carbonitrile

α-bromoacetophenone

cycloheptylidene-malononitrile

2-cyano-3-(4-chlorophenyl)-prop-2-enethioamide

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