Chemical Property of CID 6956357
Chemical Property:
- Appearance/Colour:Slight yellow powder
- Vapor Pressure:6.7E-14mmHg at 25°C
- Melting Point:218 °C
- Refractive Index:1.669
- Boiling Point:571.495 °C at 760 mmHg
- PKA:5.19±0.40(Predicted)
- Flash Point:299.43 °C
- PSA：75.01000
- Density:1.48 g/cm3
- LogP:1.54690
- Storage Temp.:Store at 0-5°C
- Sensitive.:Light Sensitive
- Solubility.:chloroform: soluble10mg/mL
- Water Solubility.:Slightly soluble in water or methanol. Soluble in glacial acetic acid or dichloromethane
- XLogP3:-0.3
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:1
- Exact Mass:361.14378429
- Heavy Atom Count:26
- Complexity:628
- Purity/Quality:
-
99% *data from raw suppliers
Levofloxacin *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
22-42/43-68-20/21/22-64-63
- Safety Statements:
26-36/37/39-36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CC[NH+](CC4)C)F)C(=O)[O-]
- Isomeric SMILES:C[C@H]1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CC[NH+](CC4)C)F)C(=O)[O-]
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Description
Levofloxacin, the optically active S-isomer of the fluoroquinolone antibiotic ofloxacin,
is two to four times more potent than ofloxacin with reportedly less side effects in treating
infections of the lower respiratory and urinary tract, prostate infections and sexually
transmitted diseases. It has broad and potent antibacterial activity over common Grampositive
and -negative aerobic pathogens and obligate anaerobes. Different from the cephem
antibiotics, levofloxacin is unique in its marked selectivity against members of the family
Enterobacteriaceae and its negligible effect on predominant anaerobes. Levofloxacin also
exhibits satisfactory antimicrobial effects in surgical infections and it may be used for
treatment of gastrointestinal infections such as traveler’s diarrhea associated with the
pathogenic Enterobacteriaceae.
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Uses
Levofloxacin is a broad-spectrum antibiotic used in pharmacokinetic?, antibiotic resistance?, and resistance prevention?studies. Levofloxacin is active against Gram-positive and Gram-negative bacteria. It inhibits DNA gyrase (type II topoisomerase) and topoisomerase IV, thereby inhibiting cell division. Antibacterial.
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Therapeutic Function
Antibacterial
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Clinical Use
Acute bacterial sinusitis Acute bacterial exacerbations of chronic bronchitis, community-acquired pneumonia Uncomplicated and complicated skin and skin structure infections Uncomplicated and complicated urinary infections including acute pyelonephritis Chronic bacterial prostatitis
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Drug interactions
Potentially hazardous interactions with other drugs
Aminophylline and theophylline: possibly increased
risk of convulsions.
Analgesics: possibly increased risk of convulsions
with NSAIDs.
Anti-arrhythmics: increased risk of ventricular
arrhythmias with amiodarone - avoid.
Anticoagulants: anticoagulant effect of coumarins
and phenindione enhanced.
Antimalarials: manufacturer advises avoid
concomitant use with artemether and lumefantrine.
Ciclosporin: half-life of ciclosporin increased by 33%;
increased risk of nephrotoxicity.
Cytotoxics: increased risk of ventricular arrhythmias
with arsenic trioxide.
Tacrolimus: may increase tacrolimus concentration.
