(5R,6R)-6-fluoro-5-(2-fluoro-5-nitro-phenyl)-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine

Base Information

Chemical Name:(5R,6R)-6-fluoro-5-(2-fluoro-5-nitro-phenyl)-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine
CAS No.:1346145-89-8
Molecular Formula:C₁₂H₁₃F₂N₃O₃
Molecular Weight:285.25
Hs Code.:

Synonyms:(5R,6R)-6-fluoro-5-(2-fluoro-5-nitro-phenyl)-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine

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Chemical Property of (5R,6R)-6-fluoro-5-(2-fluoro-5-nitro-phenyl)-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine

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Technology Process of (5R,6R)-6-fluoro-5-(2-fluoro-5-nitro-phenyl)-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine

There total 8 articles about (5R,6R)-6-fluoro-5-(2-fluoro-5-nitro-phenyl)-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1346145-83-2
(5R,6R)-6-fluoro-5-(2-fluorophenyl)-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine

: 1346145-89-8
(5R,6R)-6-fluoro-5-(2-fluoro-5-nitro-phenyl)-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine

Guidance literature:: (5R,6R)-6-fluoro-5-(2-fluorophenyl)-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine; With sulfuric acid; nitric acid; at 0 ℃; for 0.833333h;

With sodium hydroxide; In water; pH=9; Cooling with ice/water;

Reference yield:

: 1346145-55-8
(2R,3R)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-2-fluoro-3-(2-fluorophenyl)butanoate

: 1346145-89-8
(5R,6R)-6-fluoro-5-(2-fluoro-5-nitro-phenyl)-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium borohydride / tetrahydrofuran / 4 h / 0 °C

2.1: silver(l) oxide / tetra-(n-butyl)ammonium iodide / dichloromethane / 2 h / 22 °C

3.1: hydrogenchloride / 1,4-dioxane / 1 h / 22 °C

4.1: trimethylaluminum / toluene / 1 h / 22 - 80 °C

5.1: nitric acid; sulfuric acid / 0.83 h / 0 °C

5.2: pH 9

With hydrogenchloride; lithium borohydride; sulfuric acid; trimethylaluminum; nitric acid; silver(l) oxide; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;

Reference yield:

: 445-27-2
2'-Fluoroacetophenone

: 1346145-89-8
(5R,6R)-6-fluoro-5-(2-fluoro-5-nitro-phenyl)-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: titanium(IV) tetraethanolate / ethyl acetate; tetrahydrofuran / 5 h / Reflux

2.1: zinc / tetrahydrofuran / 5.25 h / Inert atmosphere; Reflux

3.1: lithium borohydride / tetrahydrofuran / 4 h / 0 °C

4.1: silver(l) oxide / tetra-(n-butyl)ammonium iodide / dichloromethane / 2 h / 22 °C

5.1: hydrogenchloride / 1,4-dioxane / 1 h / 22 °C

6.1: trimethylaluminum / toluene / 1 h / 22 - 80 °C

7.1: nitric acid; sulfuric acid / 0.83 h / 0 °C

7.2: pH 9

With hydrogenchloride; titanium(IV) tetraethanolate; lithium borohydride; sulfuric acid; trimethylaluminum; nitric acid; silver(l) oxide; zinc; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; toluene; 2.1: Reformatsky Reaction;