6-methyl-6-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-3-(2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)propan-2-yl)-1-(triisopropylsilyl)hepta-1,4-diyn-3-yl 2,3,4,5,6-pentafluorobenzoate

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Chemical Name:6-methyl-6-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-3-(2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)propan-2-yl)-1-(triisopropylsilyl)hepta-1,4-diyn-3-yl 2,3,4,5,6-pentafluorobenzoate
CAS No.:1449490-90-7
Molecular Formula:C₄₉H₅₉F₅O₆Si
Molecular Weight:867.081
Hs Code.:

6-methyl-6-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-3-(2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)propan-2-yl)-1-(triisopropylsilyl)hepta-1,4-diyn-3-yl 2,3,4,5,6-pentafluorobenzoate

Synonyms:6-methyl-6-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-3-(2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)propan-2-yl)-1-(triisopropylsilyl)hepta-1,4-diyn-3-yl 2,3,4,5,6-pentafluorobenzoate

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Chemical Property of 6-methyl-6-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-3-(2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)propan-2-yl)-1-(triisopropylsilyl)hepta-1,4-diyn-3-yl 2,3,4,5,6-pentafluorobenzoate

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Technology Process of 6-methyl-6-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-3-(2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)propan-2-yl)-1-(triisopropylsilyl)hepta-1,4-diyn-3-yl 2,3,4,5,6-pentafluorobenzoate

There total 1 articles about 6-methyl-6-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-3-(2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)propan-2-yl)-1-(triisopropylsilyl)hepta-1,4-diyn-3-yl 2,3,4,5,6-pentafluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 949589-63-3
2,6-dimethyl-2,6-bis[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]-4-heptyn-3-one

pentafluorobenzoylchloride: 2251-50-5
pentafluorobenzoylchloride

: 89343-06-6
tris-iso-propylsilyl acetylene

: 1449490-90-7
6-methyl-6-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-3-(2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)propan-2-yl)-1-(triisopropylsilyl)hepta-1,4-diyn-3-yl 2,3,4,5,6-pentafluorobenzoate

Guidance literature:: tris-iso-propylsilyl acetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

2,6-dimethyl-2,6-bis[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]-4-heptyn-3-one; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

pentafluorobenzoylchloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1039/c3cc44101f

Reference yield: 60.0%

: 1449490-90-7
6-methyl-6-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-3-(2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)propan-2-yl)-1-(triisopropylsilyl)hepta-1,4-diyn-3-yl 2,3,4,5,6-pentafluorobenzoate

: 115-19-5
2-methyl-but-3-yn-2-ol

: 1449490-91-8
(M/P)-2-methyl-5,7-bis(2-{4-[((2RS)-tetrahydro-2H-pyran-2-yl)oxy]phenyl}isopropyl)-9-(triisopropylsilyl)nona-5,6-dien-3,8-diyn-2-ol

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; In toluene; at 80 ℃; for 48h; Inert atmosphere;
DOI:10.1039/c3cc44101f

Reference yield:

: 1449490-90-7
6-methyl-6-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-3-(2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)propan-2-yl)-1-(triisopropylsilyl)hepta-1,4-diyn-3-yl 2,3,4,5,6-pentafluorobenzoate

: 1449490-89-4
(M/P)-(±)-2-methyl-5,7-bis[2-(4-hydroxyphenyl)isopropopyl]nona-5,6-dien-3,8-diyn-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / toluene / 48 h / 80 °C / Inert atmosphere

2: hydrogenchloride / tetrahydrofuran; water / 2 h / 0 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C

With hydrogenchloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; toluene;
DOI:10.1039/c3cc44101f