(S)-tert-butyl(methyl)(phenyl)silanecarboxylic acid

Base Information

Chemical Name:(S)-tert-butyl(methyl)(phenyl)silanecarboxylic acid
CAS No.:1217974-17-8
Molecular Formula:C₁₂H₁₈O₂Si
Molecular Weight:222.359
Hs Code.:

Synonyms:(S)-tert-butyl(methyl)(phenyl)silanecarboxylic acid

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Chemical Property of (S)-tert-butyl(methyl)(phenyl)silanecarboxylic acid

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Technology Process of (S)-tert-butyl(methyl)(phenyl)silanecarboxylic acid

There total 5 articles about (S)-tert-butyl(methyl)(phenyl)silanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: C₁₆H₂₈OSi₂

: 1217974-17-8
(S)-tert-butyl(methyl)(phenyl)silanecarboxylic acid

Guidance literature:: C₁₆H₂₈OSi₂; With ozone; In ethyl acetate; at -78 ℃; for 0.416667h;

With triphenylphosphine; In ethyl acetate; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1021/acs.joc.9b03350

Reference yield:

: 124-38-9,18923-20-1
carbon dioxide

: 1187840-89-6
(S)-tert-butyl-chloro-methyl-phenylsilane

: 1217974-17-8
(S)-tert-butyl(methyl)(phenyl)silanecarboxylic acid

Guidance literature:: (S)-tert-butyl-chloro-methyl-phenylsilane; With N,N-dimethyl-1-naphthalenamine; lithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

carbon dioxide; In tetrahydrofuran; at -78 - 20 ℃; optical yield given as %ee; stereospecific reaction;
DOI:10.1002/anie.200904922

Reference yield:

: C₁₅H₂₄OSi

: 1217974-17-8
(S)-tert-butyl(methyl)(phenyl)silanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / acetone; water / 20 h / 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide; n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 15 h / -78 - 20 °C / Inert atmosphere

3.1: ozone / ethyl acetate / 0.42 h / -78 °C

3.2: -78 - 20 °C / Inert atmosphere

With hydrogenchloride; n-butyllithium; ozone; lithium diisopropyl amide; In tetrahydrofuran; hexane; water; ethyl acetate; acetone;
DOI:10.1021/acs.joc.9b03350